ABSTRACT
The small size and high cohesiveness of water means that water-mediated interactions are strongly context dependent.As a result, there is still much to learn about how non-polar solutes and ions interact with themselves or each other.To help address this issue, we report here on a cavitand host, TMAX-Cl (2). Possessing two different binding sites, a shallow non-polar dish that binds hydrophobes, and a crown of ammoniums that bind anions, TMAX-Cl (2) provides insight into the hydrophobic and Hofmeister effects.We find that binding to the non-polar site is weak, suggesting that a larger surface area is needed for substantial binding.In contrast, binding to the crown of ammoniums is relatively strong, despite the high dielectric of water.These findings provide a better understanding of water-mediated interactions, and define the supramolecular properties of TMAX-Cl 2 as we continue our studies of this host and related water-soluble cavitands.
Graphical Abstract
![](/cms/asset/790e8e88-26b0-4cd0-a776-c73bf586d5a6/gsch_a_1987433_uf0001_oc.jpg)
Acknowledgments
The authors wish to thank the National Science Foundation for award CHE-1807101.
Disclosure statement
No potential conflict of interest was reported by the author(s).