ABSTRACT
Herein we report the successful synthesis and isolation of tiara[6]arene, a constitutional isomer of calix[6]arene consisting of six phenol units linked by para-substituted methylene bridges, from an isomeric mixture of asymmetrically substituted pillar[6]arene intermediates. Similar to its pentameric analogue, tiara[6]arene displays high conformational freedom in solution and rich polymorphism in the solid state. The establishment of the tiara[n]arene family (n = 5 and 6) further expands the scope of macrocyclic chemistry.
Graphical Abstract
![](/cms/asset/1fad7c03-080b-4b23-92f1-2e2873e5bd6d/gsch_a_2039653_uf0001_oc.jpg)
Disclosure statement
No potential conflict of interest was reported by the authors.