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Journal of Drug Targeting Volume 15, 2007 - Issue 2
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Research Article

Preparation, characterization, and optimization of pancreas-targeted 5-Fu loaded magnetic bovine serum albumin microspheres

Wen Juan Jia State Key Laboratory of Biotherapy, West China Medical School, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China; College of Material Science and Engineering, Sichuan University, Chengdu, 610065, People's Republic of China
,
Jian Gang Liu Department of Hepato Biliary Surgery, General Surgery, Affiliated Hospital of GuiYang Medical College, Guiyang, 550001, People's Republic of China; Department of Surgical Generalization, JiNing Medical College, JiNing, 272013, People's Republic of China
,
Yang De Zhang National Key Laboratory of Nanobiological Technology, Central South University, ChangSha, Hunan, 410008, People's Republic of China
,
Ji Wei Wang National Key Laboratory of Nanobiological Technology, Central South University, ChangSha, Hunan, 410008, People's Republic of China
,
Jun Wang Teaching Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, People's Republic of China
,
Cheng Yi Sun Department of Hepato Biliary Surgery, General Surgery, Affiliated Hospital of GuiYang Medical College, Guiyang, 550001, People's Republic of China
,
Yi Feng Pan National Key Laboratory of Nanobiological Technology, Central South University, ChangSha, Hunan, 410008, People's Republic of China
,
Chao Yu Department of Hepato Biliary Surgery, General Surgery, Affiliated Hospital of GuiYang Medical College, Guiyang, 550001, People's Republic of China
,
Guo Zheng Li National Key Laboratory of Nanobiological Technology, Central South University, ChangSha, Hunan, 410008, People's Republic of China
,
Heng Zhang State Key Laboratory of Biotherapy, West China Medical School, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China
,
Ma Ling Gou College of Material Science and Engineering, Sichuan University, Chengdu, 610065, People's Republic of China
,
Ming Jing Tu College of Material Science and Engineering, Sichuan University, Chengdu, 610065, People's Republic of China
&
Zhi Yong Qian State Key Laboratory of Biotherapy, West China Medical School, West China Hospital, Sichuan University, Chengdu, 610041, People's Republic of China
 show all
Pages 140-145 | Received 18 Jul 2006, Accepted 30 Nov 2006, Published online: 08 Oct 2008
 
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Abstract

The magnetic bovine serum albumin (BSA) microspheres (MS) were prepared by emulsification/solidification method. In this experiment, two kinds of magnetic MS, e.g. BSA MS and PEG-incorporated BSA microspheres (PMS) were prepared. The obtained MS were characterized by Malvern laser particle sizer and scanning electron microscopy (SEM). The obtained MS were spherical and about 1.3 μm in size. The magnetic responsivity and in vitro release behavior of these MS were studied in detail. The in vivo distribution and targeting delivery of 5-fluorouracil (5-Fu) magnetic MS after artery administration were studied in rat. The results showed that PMS could efficiently delivery 5-Fu to the targeted site compared with BSA MS without PEG MS and free drug.

Notes

† This work was partly financially supported by Sichuan Key Project of Science and Technology (06(05SG022-021-02)), GuiZhou Key Project of Science and Technology and Chinese Key Basic Research Program (2004CB518800 and 2004CB518807).

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