Figures & data
Table I. TEER and permeability coefficients for sucrose and propranolol across PBMVEC monolayers grown alone, in the presence of C6 co-culture or exposed to C6 astroglial factors during growth. As a comparator permeability of b.End3, Caco-2 and the membrane alone is shown. PBMVECs maintain a significant transendothelial electrical resistance particularly when co‐cultured with C6 cells or when exposed to C6 astroglial factors and ‘switched’ to serum free hydrocortisone medium. The ratio of permeabilities (propranolol:sucrose) is indicative of the level of discrimination of the BBB model between transcellular and paracellular probes. PBMVECs unlike b.End3 discriminate between the paracellular and transcellular pathways.