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Abstract
The use of polymeric carriers for drug delivery has become increasingly popular because of the ability to easily tune the physical and biological properties of macromolecules. With the growing commercial accessibility of branched and dendritic polymers, their incorporation into polymeric carriers is being explored with increased frequency. However, while a handful of systematic studies have explored the use of branched macromolecules for drug delivery, the role of polymer architecture in optimizing the polymeric carriers is not yet fully understood. Herein, the authors summarize the effect that architecture has on the basic physical properties of polymers, and review our preliminary understanding of the architectural effects on polymer-assisted drug delivery.
| Abbreviations | ||
| ATRP | = | atom transfer radical polymerization |
| CnPVP | = | poly(4-vinylpyridine) quaternized via a Cn alkyl chain |
| DNA | = | deoxyribonucleic acid |
| DOSPA | = | 2,3-dioleoyloxy-N-[2(sperminecarboxamido)ethyl]-N,N-dimethyl-1-propanaminium trifluoroacetate |
| DOTAP | = | N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride or sulfate salts |
| DOTMA | = | N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride |
| HSA | = | human serum albumin |
| MRI | = | magnetic resonance imaging |
| NMP | = | nitroxide mediated radical polymerization |
| PAMAM | = | poly(amidoamine) |
| PCL | = | Polycaprolactone |
| PEG | = | poly(ethylene glycol) |
| PEI | = | poly(ethyleneimine) |
| PHEMA | = | poly(hydroxyethyl methacrylate) |
| PHPMA | = | poly(hydroxypropylmethacrylamide) |
| PLL | = | poly(l-lysine) |
| PPI | = | poly(propylene imine) |
| PVP | = | poly(4-vinylpyridine) |
| PS | = | poly(styrene) |
| PSMA | = | poly(styrene-co-maleic anhydride) |
| RAFT | = | reversible addition fragmentation chain transfer polymerization |
| ssDNA | = | single strand DNA |
| Abbreviations | ||
| ATRP | = | atom transfer radical polymerization |
| CnPVP | = | poly(4-vinylpyridine) quaternized via a Cn alkyl chain |
| DNA | = | deoxyribonucleic acid |
| DOSPA | = | 2,3-dioleoyloxy-N-[2(sperminecarboxamido)ethyl]-N,N-dimethyl-1-propanaminium trifluoroacetate |
| DOTAP | = | N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride or sulfate salts |
| DOTMA | = | N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride |
| HSA | = | human serum albumin |
| MRI | = | magnetic resonance imaging |
| NMP | = | nitroxide mediated radical polymerization |
| PAMAM | = | poly(amidoamine) |
| PCL | = | Polycaprolactone |
| PEG | = | poly(ethylene glycol) |
| PEI | = | poly(ethyleneimine) |
| PHEMA | = | poly(hydroxyethyl methacrylate) |
| PHPMA | = | poly(hydroxypropylmethacrylamide) |
| PLL | = | poly(l-lysine) |
| PPI | = | poly(propylene imine) |
| PVP | = | poly(4-vinylpyridine) |
| PS | = | poly(styrene) |
| PSMA | = | poly(styrene-co-maleic anhydride) |
| RAFT | = | reversible addition fragmentation chain transfer polymerization |
| ssDNA | = | single strand DNA |