ceRNA networks in gynecological cancers progression and resistance

Abstract

Gynecological cancers are the second most common types of cancer in women. Clinical diagnosis of these cancers is often delayed or misdiagnosed due to lack of insight into their tumorigenesis mechanism and specific diagnostic biomarkers. Many studies have demonstrated that competing endogenous RNAs (ceRNAs) modulate the progression and resistance of gynecological cancer through microRNA (miRNA)-mediated mechanisms, which affect gene expression in multiple cancer-related pathways. Here we review studies on the involvement of the ceRNA hypothesis in the progression and resistance of gynaecological cancers to validate some ceRNAs as therapeutic targets and predictive biomarkers.

Keywords:

• Gynecological cancer
• ceRNA network
• miRNA
• ncRNA
• resistance
• target

Acknowledgements

The authors thank the researchers and study participants for their contributions.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by the National Natural Science Foundation of China [grant number 81860263] and the Natural Science Foundation of Jiangxi Province of China [grant number 20192BAB205119].