A quantitative structure-activity relationship study on serotonin 5-HT₆ receptor ligands: indolyl and piperidinyl sulphonamides

Abstract

The serotonin 5-HT₆ binding affinity of indolyl- and piperidinyl-sulphonamide derivatives has been analysed with topological and molecular features with DRAGON software. Analysis of the structural features in conjunction with the biological endpoints in combinatorial protocol in multiple linear regression (CP-MLR) led to the identification of 25 descriptors for modelling the activity. The study clearly suggested the role of an average Randic-type eigenvector-based index from adjacency matrix, VRA2, number of secondary aliphatic amines, nNHR, the sum of the topological distance between N and O, T(N···O), ring tertiary carbon atoms, nCrHR, and CH2RX type fragment, C-006, in a molecular structure to optimize the 5-HT₆ binding affinities of titled compounds. The PLS analysis confirmed the dominance of information content of CP-MLR identified descriptors for modelling the activity when compared with those of leftover ones.

Keywords:

• indolyl and piperidinyl sulphonamides
• serotonin 5-HT₆ receptor
• DRAGON descriptors
• combinatorial protocol in multiple linear regression (CP-MLR)
• partial least squares (PLS) analysis

Acknowledgements

The authors are thankful to their Institutions for providing the necessary facilities to complete this study. C.D.R.I. Communication No. 7936.