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Articles

In silico models for predicting vector control chemicals targeting Aedes aegypti

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Pages 805-835 | Received 20 May 2014, Accepted 30 Jul 2014, Published online: 02 Oct 2014

Figures & data

Figure 1. Structure of 20-hydroxyecdysone.

Figure 1. Structure of 20-hydroxyecdysone.

Figure 2. Structure of juvenile hormone III (JH3), hydroprene, kinoprene, methoprene, pyriproxyfen, and fenoxycarb.

Figure 2. Structure of juvenile hormone III (JH3), hydroprene, kinoprene, methoprene, pyriproxyfen, and fenoxycarb.

Figure 3. 2,4-dodecadienone skeleton. X = OR, SR, NHR, NR2, Alkyl; R1 = H, OR, SEt, 10-ene, 11-ene, 10-epoxy, oxo; Y = OR, SR, OCOR, Me, Et; R2 = H, Me, Cl.

Figure 3. 2,4-dodecadienone skeleton. X = OR, SR, NHR, NR2, Alkyl; R1 = H, OR, SEt, 10-ene, 11-ene, 10-epoxy, oxo; Y = OR, SR, OCOR, Me, Et; R2 = H, Me, Cl.

Figure 4. Structure of tebufenozide.

Figure 4. Structure of tebufenozide.

Figure 5. Structure of triorganotin 2,2,3,3-tetramethylcyclopropanecarboxylates (left), triphenyltin para-substituted benzoates (middle), and tricyclohexyltin para-substituted benzoates (right).

Figure 5. Structure of triorganotin 2,2,3,3-tetramethylcyclopropanecarboxylates (left), triphenyltin para-substituted benzoates (middle), and tricyclohexyltin para-substituted benzoates (right).

Table 1. Comparative toxicity (24 h-LC50 in ng/ml) of Cry19Aa and 19AL1L2 toxins against four species of mosquitoes [Citation82].

Figure 6. Structure of alantolactone and isoalantolactone.

Figure 6. Structure of alantolactone and isoalantolactone.

Figure 7. Structure of methyl vilangin, embelin, and myrsinone.

Figure 7. Structure of methyl vilangin, embelin, and myrsinone.

Figure 8. Structure of eugenol, geraniol, coumarin, eucalyptol, and carvacrol.

Figure 8. Structure of eugenol, geraniol, coumarin, eucalyptol, and carvacrol.

Figure 9. Structure of dillapiol (left) and isodillapiol (right).

Figure 9. Structure of dillapiol (left) and isodillapiol (right).

Figure 10. Structure of 1-nonanoyl-2-ethyl-piperidine (left) and 1-octanoyl-3-benzyl-piperidine (right).

Figure 10. Structure of 1-nonanoyl-2-ethyl-piperidine (left) and 1-octanoyl-3-benzyl-piperidine (right).

Figure 11. SIRIS map of the 129 insecticides used or potentially usable as larvicides (See text for the correspondence between some numbers and chemical names).

Figure 11. SIRIS map of the 129 insecticides used or potentially usable as larvicides (See text for the correspondence between some numbers and chemical names).

Figure 12. Structure of amitriptyline and doxepin.

Figure 12. Structure of amitriptyline and doxepin.

Figure 13. Structure of cis-(z)-flupenthixol and chlorpromazine.

Figure 13. Structure of cis-(z)-flupenthixol and chlorpromazine.

Figure 14. Example of triazine very active against A. aegypti.

Figure 14. Example of triazine very active against A. aegypti.

Figure 15. Structure of GCA-18.

Figure 15. Structure of GCA-18.

Figure 16. Chemicals predicted as binders to A. aegypti chorion peroxidase.

Figure 16. Chemicals predicted as binders to A. aegypti chorion peroxidase.