ABSTRACT
Background: Preeclampsia (PE) is a disorder of pregnancy associated with vitamin D (VD) deficiency. Chemerin is an adipokine significantly increased in preeclampsia and is regulated by VD.
Objectives: To determine whether VD supplementation would protect against development of PE through Chemerin reduction
Methods: PE was induced in albino rats by injection of 12.5 mg of deoxycorticosterone (DOCA). Rats were randomly divided into normal pregnant, PE group, VD supplemented PE group.
Results: VD supplementation decreased systolic blood pressure, proteinuria and decreased serum Chemerin level.
Conclusion: VD treatment reduced Chemerin level, and blood pressure in DOCA rat model of PE.
Compliance with ethical standards
Ethical approval
All applicable international, national, and/or institutional guidelines for the care and use of animals were followed. Additionally, all procedures performed involving animals were in accordance with the ethical standards of Alexandria University, Egypt. Further, no human studies were carried out by the authors for this article.
Disclosure statement
No potential conflict of interest was reported by the authors.