An in vitro study of coagulation evaluation in obstetric hemorrhage for pregnancy-induced hypertension with coagulation and platelet function analyzer

Figures & data

Table 1. Comparison between the general characteristics, routine blood test indicators, and traditional coagulation indicators of the two groups.

Indicators	Group N (mean±SD)	Group H (mean±SD)	P Value
Age	33.4 ± 3.6	32.3 ± 4.2	0.4
Pre-pregnancy BMI	23.2 ± 3.4	26.3 ± 3.6	0.003
Antenatal BMI	28.4 ± 3.2	31.3 ± 2.9	0.003
Red blood cells (10^12/L)	4.0 ± 0.4	3.8 ± 0.4	0.2
Hemoglobin (g/L)	117.0 ± 11.4	110.1 ± 12.2	0.06
Platelets (10^9/L)	211.2 ± 42.4	188.3 ± 70.0	0.2
Fibrinogen (g/L)	4.8 ± 0.8	4.3 ± 0.8	0.07
D-dimer (ng/mL)	1924.0 ± 1148.0	1470.0 ± 805.7	0.1
Thrombin time (s)	18.9 ± 1.0	19.7 ± 3.4	0.1
Prothrombin time (s)	10.2 ± 0.5	10.0 ± 0.8	0.2
Activated partial thromboplatin time (s)	25.1 ± 1.6	26.0 ± 2.5	0.2

p values with statistical differences are shown in bold.

Figure 1. Comparison of baseline levels of ACT, CR and PF between the two groups.

Comparison of baseline levels of ACT (A), CR (B), and PF (C) between group N (n = 24) and group H (n = 23). The original values of each parameter were shown. The mean and SD were calculated for each parameter, and statistical significance was determined with the Student’s t-test.

Figure 2. Comparison of ACT, CR and PF between the two groups in the hemodilution assay.

Comparison of ACT (A-B), CR (C-D), and PF (E-F) between group N and group H at varying dilution ratios. A, C, and E were presented with the original values of each parameter, the mean and SD were calculated for each parameter, and statistical significance was determined with the Student’s t-test. B, D, and F were presented with normalized values (the original values were divided by the corresponding baseline values). Median and IQR were calculated for each parameter, and statistical significance was determined using the nonparametric Mann–Whitney U-test. *, P ≤ 0.05; **, P ≤ 0.05.

Table 2. Cross-sectional comparison of the normalized values of ACT, CR, and PF in the two groups at different dilution concentrations.

	Indicators	20% dilution	35% dilution	50% dilution	65% dilution	75% dilution
Group N	ACT	15	27	38	69	99
	CR	20	40	55	66	70
	PF	10	14	10	36	62
Group H	ACT	12	19	32	52	79
	CR	20	40	51	64	73
	PF	10	11	27	40	59

The proportion of each group of conditions that changed the most at each dilution ratio is shown in bold.

Figure 3. Changes comparison of ACT, CR and PF between the two groups.

Changes in comparison of ACT (A), CR (B), and PF (C) between group N and group H after blood resupplementation. Normalized values (the original values were divided by the corresponding pre-supplementation values) of each parameter were shown. Median and IQR were calculated for each parameter, and statistical significance was determined using the nonparametric Mann–Whitney U-test.

Figure 4. Cross-sectional comparison of the normalized values of ACT, CR and PF in the two groups after blood resupplementation.

Cross-sectional comparison of the normalized values of ACT, CR, and PF in group N (A) and group H (B) after blood resupplementation. Normalized values (the original values were divided by the corresponding pre-supplementation values) of each parameter were shown. Median and IQR were calculated for each parameter.

Data availability statement

The datasets used during the current study are available from the corresponding authors on reasonable requests.