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Original Articles

Home blood pressure and cardiovascular outcomes in very elderly patients receiving antihypertensive drug therapy: a subgroup analysis of Home blood pressure measurement with Olmesartan Naive patients to Establish Standard Target blood pressure (HONEST) study

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, , ORCID Icon & ORCID Icon show all
Pages 407-413 | Received 13 Sep 2016, Accepted 26 Nov 2016, Published online: 28 Mar 2018

Figures & data

Table 1. Baseline characteristics of the study patients.

Figure 1. Changes in morning home blood pressure (A) and clinic blood pressure (B) in patients aged <75 years and ≥75 years. *P< 0.05 (vs baseline, Dunnett-Hsu test). DBP, diastolic blood pressure; SBP, systolic blood pressure; W, weeks; M, months.

Figure 1. Changes in morning home blood pressure (A) and clinic blood pressure (B) in patients aged <75 years and ≥75 years. *P< 0.05 (vs baseline, Dunnett-Hsu test). DBP, diastolic blood pressure; SBP, systolic blood pressure; W, weeks; M, months.

Table 2. Cardiovascular events during follow-up period.

Figure 2. Relationship between the major cardiovascular event and morning home systolic blood pressure (A; reference, <125 mmHg) or clinic systolic blood pressure (B; reference, <130 mmHg) during follow-up period in patients aged <75 years and ≥75 years. The Cox proportional hazards model was used, adjusting for sex, family history of cardiovascular disease, dyslipidemia, diabetes mellitus, chronic kidney disease, history of cardiovascular disease, and smoking status. *P< 0.05 (vs reference). HR: hazard ratio; CI: confidence interval.

Figure 2. Relationship between the major cardiovascular event and morning home systolic blood pressure (A; reference, <125 mmHg) or clinic systolic blood pressure (B; reference, <130 mmHg) during follow-up period in patients aged <75 years and ≥75 years. The Cox proportional hazards model was used, adjusting for sex, family history of cardiovascular disease, dyslipidemia, diabetes mellitus, chronic kidney disease, history of cardiovascular disease, and smoking status. *P< 0.05 (vs reference). HR: hazard ratio; CI: confidence interval.

Table 3. Adverse drug reactions associated with excessive blood pressure lowering by age (reported by doctors in charge).