The Impact of Timing of Fixed Dose Triple Antihypertensive Combinations on Ambulatory Blood Pressure Monitoring Parameters

Figures & data

Table 1. The general characteristics of the patients according to timing of antihypertensive drug.

	All Patients (n = 116)	Group 1 (n = 29)	Group 2 (n = 29)	Group 3 (n = 29)	Group 4 (n = 29)	P
Age (years)	62.7 ± 1.7	63.1 ± 1.9	62.7 ± 8.7	63.9 ± 12.7	61.2 ± 1.3	.807
Male sex (n – %)	38 (32.8%)	10 (34.5%)	10 (34.5%)	10 (34.5%)	8 (27.6%)	.926
Diabetes (n – %)	43 (37.1%)	8 (27.6%)	8 (27.6%)	14 (48.3%)	13 (44.8%)	.208
Hyperlipidemia (n – %)	31 (26.7%)	8 (27.6%)	5 (17.2%)	12 (41.4%)	6 (2.7%)	.167
Coronary artery disease (n – %)	22 (19.0%)	7 (24.1%)	3 (1.3%)	9 (31.0%)	3 (1.3%)	.109
Body mass index (kg/m^2)	29.9 ± 5.10	28.7 ± 6.4	29.8 ± 4.3	3.9 ± 4.9	3.5 ± 4.6	.348
Smoking (n – %)	22 (19.0%)	5 (17.2%)	4 (13.8%)	10 (34.5%)	3 (1.3%)	.089

Table 2. Ambulatory blood pressure monitoring parameters of the patients.

	All Patients (n = 116)	Group 1 (n = 29)	Group 2 (n = 29)	Group 3 (n = 29)	Group 4 (n = 29)	P
Average systolic BP over 24 hours (mmHg)	124.3 ± 14.4	126.4 ± 17.7	123.1 ± 13.6	123.4 ± 11.7	124.1 ± 14.4	.824
Average diastolic BP over 24 hours (mmHg)	75.5 ± 9.9	76.9 ± 11.1	76.3 ± 1.5	74.4 ± 8.5	74.3 ± 9.6	.686
Day-time average systolic BP (mmHg)	125.6 ± 14.1	126.8 ± 17.6	125.0 ± 13.0	124.4 ± 11.2	126.0 ± 14.2	.924
Day-time average diastolic BP (mmHg)	76.9 ± 9.9	78.7 ± 11.2	78.0 ± 1.1	75.2 ± 8.6	75.8 ± 9.5	.478
Night-time average systolic BP (mmHg)	118.4 ± 16.6	119.5 ± 19.3	116.7 ± 18.0	12.6 ± 14.1	117.0 ± 14.8	.773
Night-time average diastolic BP (mmHg)	71.0 ± 11.6	72.1 ± 13.7	7.7 ± 12.3	72.2 ± 9.2	69.2 ± 1.9	.739
Systolic BP load (%)	3.9 ± 28.6	31.0 ± 27.5	32.3 ± 32.7	3.2 ± 27.8	3.0 ± 27.6	.990
Diastolic BP load (%)	23.9 ± 24.2	27.2 ± 25.9	25.3 ± 26.8	22.4 ± 22.4	2.9 ± 22.1	.764
Dipping status – systolic (n – %)	39 (33.6%)	12 (41.4%)	12 (41.4%)	3 (1.3%)	12 (41.4%)	.025
Dipping status – diastolic (n – %)	47 (4.5%)	13 (44.8%)	15 (51.7%)	4 (13.8%)	15 (51.7%)	.008

BP: blood pressure.

Table 3. The characteristics of the patients according to dipping status.

	Dippers (n = 39)	Nondippers (n = 77)	P
Age (years)	61.8 ± 1.1	63.2 ± 11.0	.507
Male sex (n – %)	12 (3.8%)	26 (33.8%)	.457
Diabetes (n – %)	13 (33.3%)	30 (39.0%)	.351
Hyperlipidemia (n – %)	11 (28.2%)	20 (26.0%)	.482
Coronary artery disease (n – %)	8 (2.5%)	14 (18.2%)	.472
Body mass index (kg/m^2)	3.3 ± 4.9	29.8 ± 5.3	.685
Smoking (n – %)	6 (15.4%)	16 (2.8%)	.332
Average systolic BP over 24 hours (mmHg)	124.2 ± 16.7	124.3 ± 13.2	.945
Average diastolic BP over 24 hours (mmHg)	73.9 ± 9.0	76.3 ± 1.3	.217
Day-time average systolic BP (mmHg)	127.6 ± 17.1	124.6 ± 12.3	.273
Day-time average diastolic BP (mmHg)	76.6 ± 9.3	77.1 ± 1.2	.798
Night-time average systolic BP (mmHg)	11.3 ± 15.9	122.6 ± 15.4	<.001
Night-time average diastolic BP (mmHg)	65.6 ± 9.8	73.8 ± 11.5	<.001

Table 4. Logistic regression analysis to predict the independent predictors of nondipping status.

	Odds Ratio	95% Confidence Interval	P
Age	1.014	0.973–1.057	.498
Sex	1.143	0.472–2.766	.768
Group 3 vs Group 1 vs Group 2 vs Group 4	6.363 6.927 6.900	1.528–26.493 1.619–29.633 1.616–29.463	.042 .011 .009 .009
Diabetes	1.159	0.477–2.814	.744
Coronary artery disease	0.510	0.162–1.606	.250

Data availability statement

The data that support the findings of this study are available from the corresponding author, [BO], upon reasonable request.