Abstract
The presence of antimony in the human body is the result of exposure from many different sources, as is the case for any chemical element. The use of hair for diagnosing antimony exposure has become very popular because of the uncomplicated sampling and preservation, but the true utility of such studies remains uncertain. This review presents a critical discussion of the existing literature on antimony concentrations in hair, nails, and teeth, with three main objectives: (a) evaluating published data from the methodological point of view, (b) establishing a range of plausible values for antimony concentrations in these tissues, and (c) assessing statistically based correlations reported in case-control studies. From a methodological standpoint, existing data suffer from the lack of adequate certificate reference materials, low concentrations close to the detection limit of most analytical techniques and data acquisition through applying multielement techniques. These limitations are probably the underlying reason for the high dispersion of the published results and do not make it possible to establish a reliable background value for human hair from healthy, unexposed individuals. However, it is possible to estimate a concentration ceiling at 0.1 μg−1, with a probable value around 0.05 μg−1. Concerning the usefulness of antimony determinations in hair, existing results amply justify its use in occupational studies. On the other hand, the analysis of antimony concentrations in hair as an indicator of human health status does not seem to be based on any scientific evidence. The limited number of studies on human nails and teeth does not allow any conclusions to be drawn.
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