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Critical Reviews in Environmental Science and Technology Volume 52, 2022 - Issue 19
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Plant pharmacology: Insights into in-planta kinetic and dynamic processes of xenobiotics

Tomer Malchia Department of Soil and Water Sciences, Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Jerusalem, IsraelORCID Iconhttps://orcid.org/0000-0002-4125-0909View further author information
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Sara Eyalb Institute of Drug Research, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel;c David R. Bloom Centre for Pharmacy and Dr. Adolf and Klara Brettler Centre for Research in Molecular Pharmacology and Therapeutics, The Hebrew University of Jerusalem, Jerusalem, IsraelORCID Iconhttps://orcid.org/0000-0003-1275-6094View further author information
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Henryk Czosnekd Institute of Plant Sciences and Genetics in Agriculture, Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Jerusalem, IsraelORCID Iconhttps://orcid.org/0000-0002-0488-3731View further author information
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Moshe Shenkera Department of Soil and Water Sciences, Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Jerusalem, IsraelORCID Iconhttps://orcid.org/0000-0003-0600-8583View further author information
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Benny Chefetza Department of Soil and Water Sciences, Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Jerusalem, IsraelCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-0100-7661View further author information
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Pages 3525-3546 | Published online: 23 Jul 2021

Figures & data

Figure 1. Comparison of pharmacokinetic processes in the human body and in the plant. In the human body, the fate of a pharmaceutical is defined along the processes of absorption, distribution, metabolism, and excretion (ADME); in the plant, these processes are absorption, distribution, metabolism and accumulation (ADMA).

Figure 1. Comparison of pharmacokinetic processes in the human body and in the plant. In the human body, the fate of a pharmaceutical is defined along the processes of absorption, distribution, metabolism, and excretion (ADME); in the plant, these processes are absorption, distribution, metabolism and accumulation (ADMA).

Figure 2. Schematic illustration of time-dependent change in concentrations of a xenobiotic compound in animals (left) and plants (right).

Figure 2. Schematic illustration of time-dependent change in concentrations of a xenobiotic compound in animals (left) and plants (right).

Figure 3. Conceptual plant pharmacokinetic/pharmacodynamic (PK/PD) models. (A) Single-compartment model. (B) Three-compartment model. (C) Multicompartment model. TWW, treated wastewater.

Figure 3. Conceptual plant pharmacokinetic/pharmacodynamic (PK/PD) models. (A) Single-compartment model. (B) Three-compartment model. (C) Multicompartment model. TWW, treated wastewater.

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