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Materials Technology
Advanced Performance Materials
Volume 39, 2024 - Issue 1
280
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Short Communication

Al/ZnO nanoparticle as an effective nanocarrier in delivery of lenalidomide anti-multiple myeloma cancer drug

, , & ORCID Icon
Article: 2335848 | Received 01 Mar 2024, Accepted 25 Mar 2024, Published online: 02 Apr 2024

Figures & data

Figure 1. UV-Vis spectral changes of the drug solution during loading onto Al-doped ZnO nanoparticles.

Figure 1. UV-Vis spectral changes of the drug solution during loading onto Al-doped ZnO nanoparticles.

Figure 2. FT-IR spectrum of (a) Al-ZnO, (b) lenalidomide, and (c)Al/ZnO-lenalidomide.

Figure 2. FT-IR spectrum of (a) Al-ZnO, (b) lenalidomide, and (c)Al/ZnO-lenalidomide.

Figure 3. XPS pattern of the synthesized Al-ZnO nanoparticles. (a) survey spectrum; (b) Zn 2p region; (c) O1s region; and (d) Al2p region of the survey spectrum.

Figure 3. XPS pattern of the synthesized Al-ZnO nanoparticles. (a) survey spectrum; (b) Zn 2p region; (c) O1s region; and (d) Al2p region of the survey spectrum.

Figure 4. SEM pictures of (a) ZnO, (b) Al-ZnO, and (c) TEM image of Al-ZnO.

Figure 4. SEM pictures of (a) ZnO, (b) Al-ZnO, and (c) TEM image of Al-ZnO.

Figure 5. XRD pattern of Al-ZnO.

Figure 5. XRD pattern of Al-ZnO.

Figure 6. EDS pattern of (a) ZnO and (b) Al-ZnO.

Figure 6. EDS pattern of (a) ZnO and (b) Al-ZnO.

Figure 7. Absorbance spectra for ZnO and Al-ZnO (a). The Tauc plots for ZnO and Al-ZnO (b).

Figure 7. Absorbance spectra for ZnO and Al-ZnO (a). The Tauc plots for ZnO and Al-ZnO (b).

Figure 8. The in vitro release of lenalidomide at pH 6.2 and 7.4.

Figure 8. The in vitro release of lenalidomide at pH 6.2 and 7.4.

Figure 9. Three distinct pathways in the interactions of Al/ZnO with lenalidomide.

Figure 9. Three distinct pathways in the interactions of Al/ZnO with lenalidomide.

Figure 10. Cell viability of U266 against free drug and drug loaded Al-ZnO.

Figure 10. Cell viability of U266 against free drug and drug loaded Al-ZnO.

Figure 11. Cell-viability of L929 normal cells vs Al-ZnO concentration.

Figure 11. Cell-viability of L929 normal cells vs Al-ZnO concentration.

Data availability statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.