Figures & data
1 Stability of EPC/Chol (□), EPC/Chol/SM (○), EPC/Chol/SM/GM1 (♦), and EPC/Chol/SM/GM type III (dtrif;) liposomes in buffer Tes at 25°C (A) and 37°C (B) measured by the enzyme kinetics method. Each point represents mean values of experiments performed in triplicate. Percentage values varied less than ±5% between determinations.
2 Stability of EPC/Chol (□), EPC/Chol/SM (○), EPC/Chol/SM/GM1 (♦), and EPC/Chol/SM/GM type III (▾) liposomes in plasma at 25°C (A) and 37°C (B) measured by the enzyme kinetics method. Each point represents mean values of experiments performed in triplicate. Percentage values varied less than ±5% between determinations.
3 Stability of EPC/Chol (□), EPC/Chol/SM (○), EPC/Chol/SM/GM1 (♦), and EPC/Chol/SM/GM type III (▾) liposomes in acid media, pH: 2 at 37°C measured by BSA retained. Each point represents mean values of experiments performed in triplicate. Percentage values varied less than ±7% between determinations.
4 Stability of EPC/Chol (□), EPC/Chol/SM (○), EPC/Chol/SM/GM1 (♦), and EPC/Chol/SM/GM type III (▾) liposomes in bile (A) and pancreatin (B), incubated at 37°C, measured by the enzyme kinetics method. Each point represents mean values of experiments performed in triplicate. Percentage values varied less than ±5% between determinations.
5 Comparative stability of release percentage in different formulations. Column 1: EPC/Chol, column 2: EPC/Chol/SM, column 3: EPC/Chol/SM/GM1, and column 4: EPC/Chol/SM/ GM type III. Each column represents the percentage of drug released after 3 hr in acid pH (), bile (), and pancreatin (). Incubations were carried out at 37°C.
