Synthesis, Characterization and Evaluation of IPN Hydrogels for Antibiotic Release

Figures & data

1 FT-IR spectra of the samples: ···. = C, –.–.– = C-P, — = C-P-A/0.5.

2 TG thermograms of the samples: ···. = C, –.–.– = C-P, — = C-P-A/0.5.

3 Thermal degredation change with crosslinkers concentration: ··· = G-0.5, -.-.- = G-1, — = G-2.

4 The penetration-temperature curves of IPNs: ○ = G-0.5, □ = G-1, ▵ = G-2.

5 Swelling curves of C-P-A IPNs at pH 1.1: ○ = G-0.5, □ = G-1, ▵ = G-2.

6 Swelling curves of C-P-A IPNs at pH 7.4: ○ = G-0.5, □ = G-1, ▵ = G-2.

7 Swelling rate curves of C-P-A IPNs at pH 1.1: ○ = G-0.5, □ = G-1, ▵ = G-2.

8 Swelling rate curves of C-P-A IPNs at pH 7.4: ○ = G-0.5, □ = G-1, ▵ = G-2.

Swelling and diffusion parameters of IPNs at pH 1.1

IPN	Seq%	Smax%	ks × 10^5	ro × 10^5	k × 10^5	n	D × v10^6
C-P-A/0.5	630	650	4.0	180.0	60.0	0.62	2.0
C-P-A/1	570	585	6.0	210.0	83.0	0.58	1.8
C-P-A/2	560	580	7.0	230.0	84.0	0.58	2.1

9 Plots of lnF versus lnt of C-P-A IPNs at pH 1.1: ○ = G-0.5, □ = G-1, ▵ = G-2.

10 Plots of lnF versus lnt of C-P-A IPNs at pH 7.4: ○ = G-0.5, □ = G-1, ▵ = G-2.

Swelling and diffusion parameters of IPNs at pH 7.4

IPN	Seq%	Smax%	ks × 10^5	ro × 10^5	k × 10^5	n	D × 10^6
K-P-A/0.5	600	610	6.0	240.0	90.0	0.58	2.2
K-P-A/1	540	560	7.0	220.0	100.0	0.55	1.5
K-P-A/2	520	530	8.0	230.0	100.0	0.56	1.7

11 In vitro amoxicillin release profiles from C-P-A IPNs at pH 1.1: ○ = G-0.5, □ = G-1, ▵ = G-2.

12 In vitro amoxicillin release profiles from C-P-A IPNs at pH 7.4: ○ = G-0.5, □ = G-1, ▵ = G-2.

Release kinetic parameters of IPNs in solutions with different pH

	pH 1.1				pH 7.4
IPN	R%	Cmax mg L^−1	krel×10^3 s^−n	ro×10^5 mg L^−1 s^−1	R%	Cmax mg L^−1	krel×10^3 s^−n	ro×10^5 mg L^−1 s^−1
C-P-A/0.5	98	86	117	825	83	65	580	2480
C-P-A/1	88	75	200	1110	73	58	930	3080
C-P-A/2	84	69	250	1210	71	56	1000	3130

13 Release rate curves of C-P-A IPNs at pH 1.1: ○ = G-0.5, □ = G-1, ▵ = G-2.

14 Release rate curves of C-P-A IPNs at pH 7.4: ○ = G-0.5, □ = G-1, ▵ = G-2.

15 Plots of lnC versus lnt of C-P-A IPNs at pH 1.1: ○ = G-0.5, □ = G-1, ▵ = G-2.

16 Plots of lnC vs. lnt of C-P-A IPNs at pH 7.4: ○ = G-0.5, □ = G-1, ▵ = G-2.

Release diffusion parameters of IPNs in solutions with different pH

	pH 1.1			pH 7.4
IPN	Ceq mg L^−1	k × 10^3 s^−n	nrel	Ceq mg L^−1	k × 10^3 s^−n	nrel
C-P-A/0.5	74	12.8	0.94	61	18.3	0.97
C-P-A/1	68	20.3	0.88	55	36.8	0.84
C-P-A/2	64	23.7	0.85	54	37.0	0.84