Solubilization and Pharmacokinetic Behaviors of Sodium Cholate/Lecithin-Mixed Micelles Containing Cyclosporine A

Figures & data

Figure 1

Figure 2 The influence of lecithin concentration and sodium cholate /lecithin molar ratio on the solubility of cyclosporin A in mixed micelles (n = 3).

Figure 3 The influence of dilution medium on the drug content in mixed micelles (n = 3).

Figure 4 Effect of dilution on size of mixed micelles (n = 3).

Figure 5 Mean blood concentration profile in rabbits after intravenous infusion of mixed micelles and Sandimmun (n = 6).

Table 1 Pharmacokinetic and moment parameters of cyclosporin A in rabbits after intravenous infusion of mixed micelles and Sandimmun (n = 6)

Parameters	K12 (h^−1)	K21 (h^−1)	K10 (h^−1)	α(h^−1)	β (h^−1)	(t1/2)α (h)	(t1/2)β (h)	AUC(μg · h/ml)	MRT (h)
Mixed micelles	3.62 ± 1.37	0.80 ± 0.27	2.65 ± 1.05	6.76 ± 2.44	0.31 ± 0.12	0.12 ± 0.044	2.58 ± 0.91	9.10 ± 1.28	1.95 ± 0.39
Sandimmun	2.50 ± 1.39	0.60 ± 0.19	2.38 ± 0.30	5.35 ± 1.67	0.27 ± 0.08	0.14 ± 0.03	2.74 ± 0.62	8.20 ± 0.57	1.85 ± 0.26