Silica-Based Mesoporous Materials as Drug Delivery System for Methotrexate Release

Figures & data

TABLE 1 Chemical and porous properties of MCM-41 and Al-MCM-41 calcined samples

Sample	Si/Al	ac (Å)	Dp (Å)	SBET (m^2/g)	Vp (cm^3/g)
Al-MCM-41(16)	18.4	45.6	39	1097	0.89
MCM-41(16)	—	42.6	35	980	0.69
Al-MCM-41(12)	14.5	38.7	30	1144	0.53
MCM-41(12)	—	41.2	27	321	0.31
Al-MCM-41(10)	50.0	34.5	25	814	0.40

Si/Al = Silica/aluminium, a_c = lattice parameter of calcinated material, Dp = pore diameter, S_BET = BET surface area, Vp = Pore volume.

FIG. 1 Nitrogen (▵) ads.-(○) des. isotherms for Al-MCM-41 (16) (a), Al-MCM-41(12) (b), Al-MCM-41(10) (c) samples.

TABLE 2 Amount of adsorbed methotrexate through the different soaking procedures

	Soaking procedure (mg drug/g sample)
Sample	SSD	SSB	DSB
Al-MCM-41(16)	11.3	17.7	121.0
MCM-41(16)	1.16	—	—
Al-MCM-41(12)	26.4	23.9	124.0
MCM-41(12)	5.8	—	—
Al-MCM-41(10)	21.1	18.0	152.0

SS_D = single soaking DMSO, SS_B = single soaking with sodium phosphate buffer, DS_B = double soaking with sodium buffer.

FIG. 2 X-ray diffraction pattern of sample Al-MCM-41(12) after double soaking with sodium buffer procedure.

FIG. 3 Release profiles of MTX using single soaking DMSO procedure.

FIG. 4 Release profiles of MTX using double soaking with sodium buffer procedure.