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Research Article

Sustained Ocular Drug Delivery from a Temperature and pH Triggered Novel In Situ Gel System

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Pages 507-515 | Received 28 Dec 2006, Accepted 05 Feb 2007, Published online: 10 Oct 2008

Figures & data

TABLE 1 Combinations of chitosan/ Pluronic F-127 studied

TABLE 2 Ingredients of the developed in situ gel formulation

TABLE 3 Physicochemical properties of the developed in situ gel formulation

TABLE 4 Scoring chart for HET-CAM test

FIG. 1 In vitro release drug release profile from developed in situ gel system. Values are expressed as mean ± S.D. (n = 6)

FIG. 1 In vitro release drug release profile from developed in situ gel system. Values are expressed as mean ± S.D. (n = 6)

FIG. 2 In vitro drug transcorneal permeation profile from different formulations. Values are expressed as mean ± S.D. (n = 6)

FIG. 2 In vitro drug transcorneal permeation profile from different formulations. Values are expressed as mean ± S.D. (n = 6)

TABLE 5 Recorded scores in HET-CAM test

FIG. 3 Dynamic scintigraphic images of rabbit's eye up to 20 min after administration of (a) plain drug solution and (b) developed in situ gel system.

FIG. 3 Dynamic scintigraphic images of rabbit's eye up to 20 min after administration of (a) plain drug solution and (b) developed in situ gel system.

FIG. 4 Time-activity curve shows precorneal drainage of various formulations.

FIG. 4 Time-activity curve shows precorneal drainage of various formulations.

FIG. 5 Static whole body image after 2 h administration of (a) plain drug solution and (b) developed in situ gel system.

FIG. 5 Static whole body image after 2 h administration of (a) plain drug solution and (b) developed in situ gel system.

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