Modulation of a Pulsatile Release Drug Delivery System Using Different Swellable/Rupturable Materials

Figures & data

FIG. 1 SEM photomicrograph of a cross-section of a pulsatile release tablet with different swelling materials and a rupturable ethylcellulose coating. i = Dense tablet core layer, ii = Swelling layer, iii = Rupturable layer.

FIG. 2 Rupture sequence of pulsatile release tablet in phosphate buffer pH 6.8.

TABLE 1 Swelling Index of PRTs containing different swelling materials and coated with different ethylcellulose levels

		Swelling index ± S.D. at Time (min)
Swellable materials	Ethylcellulose levels (mg/cm^2)	15	30	60	90	120	150	180	240	270
Explotab	1.4	R	—	—	—	—	—	—	—	—
	2.2	11.11 ± 0.03	15.97 ± 0.04	R	—	—	—	—	—	—
	2.8	4.76 ± 0.03	8.68 ± 0.01	16.67 ± 0.03	21.58 ± 0.02	R	—	—	—	—
Croscarmellose	1.4	15.61 ± 0.02	R	—	—	—	—	—	—	—
sodium	2.2	9.09 ± 0.01	12.28 ± 0.02	19.66 ± 0.02	R	—	—	—	—	—
	2.8	3.85 ± 0.03	6.98 ± 0.03	9.91 ± 0.02	13.79 ± 0.02	18.37 ± 0.03	23.20 ± 0.03	R	—	—
Starch RX 1500	1.4	7.41 ± 0.01	13.79 ± 0.04	R	—	—	—	—	—	—
	2.2	3.38 ± 0.01	5.21 ± 0.02	11.11 ± 0.02	16.99 ± 0.03	20.63 ± 0.02	R	—	—	—
	2.8	0.50 ± 0.01	1.96 ± 0.02	3.85 ± 0.04	6.44 ± 0.02	11.10 ± 0.03	14.90 ± 0.02	18.36 ± 0.04	23.73 ± 0.01	R

*R = Ruptured tablet

FIG. 3 Effect of coating level on the percent water uptake of pulsatile release tablet containing Explotab.

FIG. 4 Effect of coating level on the percent water uptake of pulsatile release tablet containing Croscarmellose sodium.

FIG. 5 Effect of coating level on the percent water uptake of pulsatile release tablet containing Starch RX 1500.

FIG. 6 Effect of coating level on the lag time of PRTs containing different swelling materials.

FIG. 7 Effect of coating level on the drug release from Explotab-containing pulsatile release tablets.

FIG. 8 Effect of coating level on the drug release from Croscarmellose sodium-containing pulsatile release tablets.

FIG. 9 Effect of coating level on the drug release from Starch RX1500-containing pulsatile release tablets.