In Vitro Permeation Studies of Nanoemulsions Containing Ketoprofen as a Model Drug

Figures & data

TABLE 1  Composition of the selected nanoemulsion formulation

	Nanoemulsion (g)
	I	II	III	IV	V
Ketoprofen	0.8	0.8	0.8	0.8	0.8
Benzyl alcohol	2	4	2	2	2
Ethanol	2	2	4	2	2
Solutol^® HS 15	2	2	2	4	1
Water	q.s. to 100

FIG. 1  Pseudoternary phase diagrams of emulsion composed of Oil/CoS (BA/ethanol). surfactant (SLT), and water. (NE represents nanoemulsion region).

TABLE 2  Mean particle size of nanoemulsion

nanoemulsion	Mean particle size (nm)
I	58.4 ± 6.2
II	51.9 ± 5.6
III	40.8 ± 6.7
IV	20.1 ± 3.8
V	226.3 ± 12.7

Mean ± SD, n = 3.

FIG. 2  The change of mean particle size of ketoprofen-loaded nanoemulsion for 90 days. Average particle size of the NE2. The sample was stored at 4°C.

FIG. 3  Permeation profiles of ketoprofen through excised mouse skins from emulsion of different compositions and control. (Control: ketoprofen contained ethanol solution, permeation time = 24 hr) (mean ± SD, n = 3).

FIG. 4  Effects of SLT content in emulsion on permeation of ketoprofen through mice skin (mean ± SD, n = 3).

FIG. 5  Effect of oil content in emulsion on permeation of ketoprofen through mice skin. (mean ± SD, n = 3).