Multi-Unit Floating Alginate System: Effect of Additives on Ciprofloxacin Release

Figures & data

TABLE 1  Composition variables of the fabricated alginate beads

						Floating character
Batch code	Gellan gum (% w/w)	Chitosan (% w/w)	HPMC (% w/w)	Starch (% w/w)	Incorporation efficiency (%)	Lag time (see)	Duration (hr)
Control	—	—	—	—	52.81 ± 2.64	No lag time	18–20
BG1	20	—	—	—	64.66 ± 1.17	< 30	10–12
BG2	40	—	—	—	62.50 ± 2.21	< 30	10–12
BC1	—	10	—	—	70.32 ± 2.04	< 45	8–9
BC2	—	20	—	—	72.94 ± 1.78	< 45	8–10
BH1	—	—	20	—	76.54 ± 2.00	< 30	> 12
BH2	—	—	40	—	77.03 ± 2.34	< 30	18–20
BH3	—	—	60	—	78.95 ± 1.92	< 30	∼24
BS1	—	—	—	10	74.38 ± 3.10	< 120	7–8
BS2	—	—	—	20	73.86 ± 2.67	< 120	∼8

All batches were composed of ciprofloxacin (1% w/v), sodium alginate (2% w/v), and calcium carbonate (1% w/w).

FIG. 1  Equilibrium % water uptake of various batches prepared with added excipients in SGF (pH 1.2). *p < 0.05 in comparison to control batch.

FIG. 2  Ciprofloxacin release from gellan gum and starch containing beads in comparison to control batch. **p < 0.001 vs. control batch; **p < 0.001 vs. control and starch-blended beads.

FIG. 3  Effect of HPMC and chitosan blending on drug release from floating alginate beads. *p < 0.001 vs. control batch: **p < 0.001 vs. control and chitosan-blended beads.

TABLE 2  Mechanism of ciprofloxacin release from the fabricated alginate beads

	Correlation coefficient (r^2)
Batch code	Zero order	First order	Higuchi	Release exponent (n)	t50% (hr)	t75% (hr)
Control	0.9537	0.9183	0.9763	0.52	0.73	1.17
BG1	0.8927	0.9849	0.9903	0.58	1.08	2.08
BG2	0.9244	0.9833	0.9887	0.68	1.29	2.50
BC1	0.9487	0.9854	0.9963	0.63	1.49	2.88
BC2	0.9763	0.9808	0.9950	0.65	1.78	3.24
BH1	0.9670	0.9890	0.9978	0.73	2.06	3.84
BH2	0.9758	0.9682	0.9969	0.84	2.38	4.32
BH3	0.9880	0.9516	0.9863	0.60	2.72	4.73
BS1	0.9460	0.9543	0.9975	0.83	1.21	2.34
BS2	0.9657	0.9782	0.9982	0.89	1.42	2.60