Biodegradable polymer films for releasing nanovehicles containing sirolimus

Figures & data

Figure 1.  A degradation product of SRL reported by Ferron and Jusko (10) and Trepanier et al. (11).

Figure 2.  The chemical structure of PMB30W.

Figure 3.  SEM images of the air contact surface during incubation in PBS. Film A: (A) before; (B) after 3 days. Film B: (C) before; (D) after 3 days.

Figure 4.  Release profiles of (A) SRL and (B) 34-hydroxy SRL from PLGC/SRL films during incubation in PBS with BSA (diamonds) and that in PBS with BSA + PMB3OW (cross). Data points and error bars represent means ± SD for n = 4.

Figure 5.  The size distribution of nanovehicles: PMB30W nanovehicles (dotted line); PMB30W nanovehicles incorporating SRL (broken line); the nanovehicles released from Film A (solid line).

Figure 6.  Release profiles of (A) SRL and (B) 34-hydroxy SRL from PLCG/SRL films (black squares), Film A (white circles), and Film B (white triangles) during incubation in PBS with BSA. Data points and error bars represent mean ± SD for n = 4–5.

Ferron GM, Jusko WJ. (1998). Species differences in sirolimus stability in humans, rabbits, and rats. Drug Metab Dispos, 26, 83–4.

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Trepanier DJ, Gallant H, Legatt DF, Yatscoff RW. (1998). Rapamycin: distribution, pharmacokinetics and therapeutic range investigations: an update. Clin Biochem, 31, 1345–51.

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