Assessment of methylsulfonylmethane as a permeability enhancer for regional EDTA chelation therapy

Figures & data

Figure 1.  Higher concentrations of methylenesulfonylmethane increased the rate of transport of methylene blue  1 mg/ml across a porcine intestinal membrane as measured with a spectrometer set at 668 nm over a 2-h time period.

Figure 2.  Methylenesulfonylmethane (MSM) increased the rate of transport of ciprofloxacin 0. 5 mg/ml better than ciprofloxacin alone across a porcine intestinal membrane as measured with a spectrometer set at 275 nm over a 2-h time period.

Figure 3.  Study determined if the porcine intestinal membrane impermeability recovered after exposure and removal of MSM. Membrane soaked in MSM for 24 h then washed was no more permeable to methylene blue than control solution of methylene blue without MSM. Concurrent MSM increased the permeability of methylene blue through the membrane.

Figure 4.  C¹⁴-EDTA combined with and without the carrier MSM applied topically to rat eyes. MSM facilitated the delivery of EDTA into the aqueous.

Figure 5.  C¹⁴-EDTA applied topically together with the carrier MSM penetrated the various rat ocular tissues, including the aqueous, cornea, lens, vitreous, and retina+choroid.