Figures & data
Figure 1. Influence of cross-linking time on 5-FU encapsulation efficiency in 5-FU-loaded microparticles.
Figure 2. Influence of cross-linking time on swelling ratio of 5-FU-loaded microparticles (3.5 wt% chitosan).
Figure 3. Influence of chitosan concentrations on cumulative release of 5-FU from 5-FU-loaded microparticles (chitosan/PEG = 70/30, 3 wt% TPP, and cross-linking time = 4 h) in (A) pH = 7.4 and (B) pH = 1.2 of PBS (mean ± SD, n = 3).
Figure 4. Effect of TPP concentrations on the 5-FU release behavior from 5-FU loaded microparticles (3.5 wt% chitosan, chitosan/PEG = 70/30, and cross-linking time = 4 h) in (A) pH = 7.4 and (B) pH = 1.2 of PBS (mean ± SD, n = 3).
Figure 5. Effect of cross-linking time on the release of 5-FU from 5-FU-loaded microparticles (3.5 wt% chitosan, chitosan/PEG = 70/30, and 3 wt% TPP) in (A) pH = 7.4 and (B) pH = 1.2 of PBS (mean ± SD, n = 3).
Figure 6. The surface morphology of (A) the microparticle and (B) the 5-FU-loaded microparticle prepared with 3.5 wt.% chitosan, chitosan/PEG = 70/30, 3 wt.% TPP, and cross-linking time = 4 hr.
Figure 7. The surface morphology of the 5-FU-loaded microparticle prepared with (A) 2.1 wt.% chitosan, chitosan/PEG = 70/30, 3 wt% TPP, (B) 3.5 wt% chitosan, chitosan/PEG = 70/30, 3 wt% TPP, (C) 3.5 wt% chitosan, chitosan/PEG = 70/30, 1 wt% TPP, and (D) 3.5 wt% chitosan, chitosan/PEG = 70/30, 3 wt% TPP, and cross-linking time = 4 h.
Figure 8. Release of 5-FU from 5-FU-loaded microparticles (3.5 wt% chitosan, chitosan/PEG = 70/30, 3 wt% TPP, and cross-linking time = 4 h) in (A) pH = 7.4 and (B) pH = 1.2 of PBS vs square root time.
