Development of mannosylated liposomes for bioadhesive oral drug delivery via M cells of Peyer’s patches

Figures & data

Figure 1.  SEM (left) and TEM (right) images of ACV-lip (top), ManN-ACV-lip (middle), and PAM-ACV-lip (bottom).

Table 1.  Zeta potential, particle size, entrapment efficiency (% EE), and loading capacity (% LC) of ACV-lip, ManN-ACV-lip, and PAM-ACV-lip.

Formulation	Mean ± SD
	Zeta potential^a (mV)	Particle size^b (nm)	% EE^b	% LC^b
ACV-lip	−4.52 ± 1.53	324 ± 13	95.51 ± 0.15	47.31 ± 0.08
ManN-ACV-lip	−26.73 ± 3.07	371 ± 7	81.88 ± 0.11	42.45 ± 0.06
PAM-ACV-lip	0.54 ± 1.63	233 ± 8	86.79 ± 0.05	45.17 ± 0.03

^aAverage from 10 determinations; ^bAverage from three batches.

Figure 2.  Percentage drug absorbed through mice ileum of ACV suspension, ACV-lip, ManN-ACV-lip, and PAM-ACV-lip after incubated at 37°C for 1 h. Data are the average of 10 different experiments and the error bars are standard deviations.

Figure 3.  Permeability coefficient through mice ileum of acyclovir suspension, ACV-lip, ManN-ACV-lip, and PAM-ACV-lip after incubated at 37°C for 1 h. Data are the average of 10 different experiments and the error bars are standard deviations.