Figures & data
Figure 1. SEM image of (a) uncoated calcium alginate microspheres; (b) polyelectrolyte-coated alginate microspheres.
Figure 2. Particle size distribution of uncoated calcium alginate microspheres.
Figure 3. Zeta potential of uncoated and polyelectrolyte-coated alginate microspheres.
Figure 4. Effect of initial drug content on burst release of dexamethasone-loaded uncoated microspheres.
Figure 5. (a) Comparative release profile of uncoated and polyelectrolyte-coated dexamethasone-loaded alginate microspheres in 0.01 M PBS (pH 7.4) at 37°C. Mean ± SD (n = 3); (b) Initial burst release profile for 24 h.
Figure 6. Comparative release profile of uncoated and polyelectrolyte-coated dexamethasone-loaded alginate microspheres in 0.01 M PBS (pH 7.4) at 37°C. Mean ± SD (n = 3). (a) Initial burst release profile for 24 h; (b) Cumulative release for 30 days, and (c) Zero order release kinetic data of combined system (uncoated and polyelectrolyte-coated microspheres) for the initial 18 days.
Table 1. Mathematical modeling on zero order release kinetics along with the drug diffusivities (D) from the uncoated and polyelectrolyte-coated alginate microspheres.
Table 2. Zero order release kinetics data fitting to the combined system of uncoated and (PAH/PSS)1-coated dexamethasone-loaded alginate microspheres.
Figure 7. Cytotoxicity results of uncoated and polyelectrolyte-coated dexamethasone-loaded alginate microspheres.
