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Review Article

A novel strategy to achieve effective drug delivery: exploit cells as carrier combined with nanoparticles

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Pages 83-91 | Received 04 Jul 2016, Accepted 28 Aug 2016, Published online: 03 Feb 2017

Figures & data

Figure 1. (A) Illustration of CPP mediated RBCs encapsulation technology (He et al., Citation2014). (B) The morphology of untreated normal RBCs and LMWP-ASNase-encapsulated RBCs by scanning electron microscopic images. (C) Pharmacokinetic profiles of ASNase in DBA2 mice and Kaplan–Meier survival curve for DBA/2 mice bearing L5178Y lymphoma cells (Kwon et al., Citation2009).

Figure 1. (A) Illustration of CPP mediated RBCs encapsulation technology (He et al., Citation2014). (B) The morphology of untreated normal RBCs and LMWP-ASNase-encapsulated RBCs by scanning electron microscopic images. (C) Pharmacokinetic profiles of ASNase in DBA2 mice and Kaplan–Meier survival curve for DBA/2 mice bearing L5178Y lymphoma cells (Kwon et al., Citation2009).

Figure 2. Schematic representation of process of leukocyte transmigration endothelium under inflammation.

Figure 2. Schematic representation of process of leukocyte transmigration endothelium under inflammation.

Figure 3. (A) Alexa Fluor 680-labeled BMMs loaded with nanozyme. (B) Alexa Fluor 680-labeled nanozyme administered alone (Brynskikh et al., Citation2010).

Figure 3. (A) Alexa Fluor 680-labeled BMMs loaded with nanozyme. (B) Alexa Fluor 680-labeled nanozyme administered alone (Brynskikh et al., Citation2010).

Figure 4. (A) NPs absorbed onto RBCs surface by no-covalent coupling (Chambers & Mitragotri, Citation2004). (B) Covalently coupled NPs onto T-cell membrane via thiol-maleimide conjugation (Stephan et al., Citation2010). (C) NPs internalization by macrophages (Choi et al., Citation2012).

Figure 4. (A) NPs absorbed onto RBCs surface by no-covalent coupling (Chambers & Mitragotri, Citation2004). (B) Covalently coupled NPs onto T-cell membrane via thiol-maleimide conjugation (Stephan et al., Citation2010). (C) NPs internalization by macrophages (Choi et al., Citation2012).

Figure 5. Schematic representation of the preparation process of the RBC-membrane-coated PLGA NPs (Hu et al., Citation2012).

Figure 5. Schematic representation of the preparation process of the RBC-membrane-coated PLGA NPs (Hu et al., Citation2012).