Figures & data
Figure 1. Characterization of CUR DHA ME: TEM micrograph of CUR DHA ME (A) and SANS Image of CUR DHA ME (B).
Figure 2. (A) Intravenous CUR concentration vs. time profiles for plasma (a) and brain (b) following intravenous administration of the CUR in MEs or CUR solution to SD rats. (B) Intranasal CUR concentration versus time profiles plasma (a) and brain CUR (b) following intranasal administration of the CUR in MEs or CUR solution to SD rats.
Table 1. Plasma and brain pharmacokinetics parameters upon intravenous administration of the MEs of CUR or CUR solution in SD rats.
Table 2. Plasma and brain pharmacokinetics parameters upon intranasal administration of the MEs of CUR or CUR solution in SD rats.
Figure 3. Photomicrographs of positive control [1% sodium deoxycolate solution, (A, 7 days) no cilia on the mucosa was observed (E, 14 days)], Vehicle control* [saline, (B, 7 days) (F, 14 days)], Blank DHA ME* [(C, 7 days) (G, 14 days)] and CUR DHA ME * [(D, 7 days) (H, 14 days)] (10 × 40 magnification, n = 4). *(a) Moderate infiltration, (b) Degenerative changes in nasal epithelium, (c) Severe leucocytic infiltration, (d) Extensive desquamation of nasal epithelium, (e) Intact nasal epithelium with healthy appearance.
![Figure 3. Photomicrographs of positive control [1% sodium deoxycolate solution, (A, 7 days) no cilia on the mucosa was observed (E, 14 days)], Vehicle control* [saline, (B, 7 days) (F, 14 days)], Blank DHA ME* [(C, 7 days) (G, 14 days)] and CUR DHA ME * [(D, 7 days) (H, 14 days)] (10 × 40 magnification, n = 4). *(a) Moderate infiltration, (b) Degenerative changes in nasal epithelium, (c) Severe leucocytic infiltration, (d) Extensive desquamation of nasal epithelium, (e) Intact nasal epithelium with healthy appearance.](/cms/asset/67861837-a781-4434-97c5-7dffbd041d50/idrd_a_1233593_f0003_c.jpg)
