Plasma concentration of metformin and dexamethasone after administration through Osseogate

Figures & data

Figure 1. Implant mediated drug delivery system, which release drug through novel route of administration, Osseogate.

Figure 2. Plasma concentration of metformin hydrochloride and dexamethasone administered through Osseogate. The bottom is the superimposition of the two graphs after scaling the concentration.

Table 1. Mean pharmacokinetic parameters for metformin hydrochloride and dexamethasone administered via Osseogate.

	Metformin hydrochloride	Dexamethasone
Cmax (ng/ml)	205.77	62.116
Tmax (h)	2	4
AUClast (ng/ml·h)	2874.02	1870.21
AUC∞ (ng/ml·h)	2874.02	NA^a
MRT (h)	15.05	NA^a
Half life (h)	10.43	NA^a

C_max: the maximum plasma concentration; T_max: the time at which the C_max is achieved; AUC_last: area under curve until the end of observation; AUC_∞: area under curve from zero to infinity; MRT: mean residence time.

^a These values were unavailable because the plasma concentration of dexamethasone was still rising at the end of observation.