Comparison of pharmacokinetics and drug release in tissues after transarterial chemoembolization with doxorubicin using diverse lipiodol emulsions and CalliSpheres Beads in rabbit livers

Figures & data

Figure 1. Arterial angiogram of a rabbit liver (A) before embolization and (B) immediately after embolization with CBDOX and PVA. The hepatic artery trunk was occluded with CBDOX and PVA after embolization.

Figure 2. The plasma concentration curves of doxorubicin after liver artery embolization in two groups (n = 5). Symbols: (filled triangle) cTACE group; (filled circle) CBDOX group.

Table 1. Pharmacokinetic parameters based on noncompartmental pharmacokinetic analyses for embolization with CBDOX or cTACE of doxorubicin solution to rabbit livers (n = 5).

Parameters	Units	TACE with CBDOX	cTACE
Cmax	ng/mL	39.85 ± 13.86	225.91 ± 64.88^#
AUC(0–t)	mg/L*h	191.18 ± 40.36	275.94 ± 27.45^#
MRT(0–t)	h	157.78 ± 130.86	26.58 ± 12.45
T1/2	h	109.84 ± 90.88	23.17 ± 10.43

C_max: maximum plasma concentration; AUC: area under the curve; T_1/2: half-time; MRT: mean residence time.

# p<.01.

Figure 3. The tissue concentration curves of doxorubicin after liver artery embolization with CBDOX to rabbits (n = 5). Symbols: (filled triangle) 1 month group; (filled circle) 1 week group.