Mucosal co-delivery of ketorolac and lidocaine using polymeric wafers for dental application

Figures & data

Table 1. The design of the nine prepared formulae.

Formula	SA:PVP (X1)	Glycerol % (X2)	Ketorolac	Lidocaine HCl	Lactose %
F1	1:1	0	2%	2%	5
F2	1:1	5	2%	2%	5
F3	1:1	10	2%	2%	5
F4	2:1	0	2%	2%	5
F5	2:1	5	2%	2%	5
F6	2:1	10	2%	2%	5
F7	1:2	0	2%	2%	5
F8	1:2	5	2%	2%	5
F9	1:2	10	2%	2%	5

Figure 1. SEM micrographs of drug loaded wafers.

Figure 2. Wafers’ hydration capacity.

Figure 3. (a) Cumulative percentage release of ketorolac from the nine wafer formulations and (b) cumulative percentage release of lidocaine from the nine wafer formulations.

Table 2. Ex vivo mucoadhesive time of the nine tested drug formulations.

Formula	Mucoadhesive time (min)
F1	263
F2	299
F3	339
F4	301
F5	310
F6	364
F7	242
F8	287
F9	321

Figure 4. Clinical photographs taken preoperatively and after 1 week post-operatively.