Development of novel bioadhesive granisetron hydrochloride spanlastic gel and insert for brain targeting and study their effects on rats

Figures & data

Table 1. The composition of GSpNG formulae.

Formula	Spanlastic dispersions	HPMC (%w/w)	Carbopol (%w/w)
G1	The chosen Spanlastic dispersions S4 (10 mg GH, 140 mg span 60, 60 mg tween 80) S9 (10 mg GH, 140 mg span 60, 60 mg tween 60)	2%	–
G2		2%	–
G3		4%	–
G4		4%	–
G5		–	1%
G6		–	1%
G7		–	2%
G8		–	2%

Table 2. The composition of the GHSpNIs.

Formula	Spanlastic dispersions	HPMC (%w/w)	Gelatin (%w/w)	Glycine (%w/w)	Mannitol (%w/w)
F1	The best chosen dispersionS4 (10 mg GH, 140 mg span 60,60 mg tween 80)S9 (10 mg GH, 140 mg span 60, 60 mg tween 60)	2%	–	0.5%	20
F2		2%	–	0.5%	20
F3		2%	–	1%	20
F4		2%	–	1%	20
F5		–	1%	0.5%	20
F6		–	1%	0.5%	20
F7		–	1%	1%	20
F8		–	1%	1%	20

Figure 1. In vitro release of drug from the GHSpNGs in distilled water.

Figure 2. The release of GH from the prepared GHSpNIs.

Figure 3. Mean GH concentration–time profile in the plasma of rats for (IV, GHSpNGs, and GHSpNIs).

Figure 4. Mean GH concentration–time profile in the brain of rats (IV, GHSpNG, and GHSpNI).