http://orcid.org/0000-0002-1963-7170
Figures & data
Figure 1. (A) Image of administering 5-FU around an artificially generated cancer tissue using a hollow micro needle. (B) A sustained 5-FU sol-gel formulation (purple area) was administered around the tumor to deliver the drug into the tumor.
Figure 2. Drug release profiles of free FITC and FITC sol-gel formulation after injection in collagen gel. (A) Diameters at the half maximum concentration of the drug. (B) The ratio of the relative concentration value (measured concentration/initial concentration) at 1.3 cm of the distance from the center over time.
Figure 3. Assessment of the cytotoxic effects regarding administration methods of Free 5-FU. The effect of the total dose of the free 5-FU at once was compared with the effect of the total dose of free 5-FU administered in multiple times to see the effect of the sustained release.
Figure 4. Changes in tumor size of gastric carcinoma after administration of gel only w/o 5-FU and 5-FU gel. Human gastric cancer cells were xenografted into 8 rats to evaluate the efficacy of 5-FU gel.
Figure 5. Comparison of mean tumor volume by peri-tumor administration of gel only w/o 5-FU, free 5-FU, and 5-FU gel.
Figure 6. Apoptosis and proliferation index of the (A & D) control, (B & E) partial response, and (C & F) complete response groups.
