Pharmacokinetic evaluation of quetiapine fumarate controlled release hybrid hydrogel: a healthier treatment of schizophrenia

Figures & data

Figure 1. Dynamic swelling of Gel/HPMC with increasing concentration of (A) gelatin (B) HPMC (C) glutaraldehyde, gel fraction of Gel/HPMC with increasing concentration of (D) gelatin (E) HPMC (F) glutaraldehyde, porosity of Gel/HPMC with increasing concentration of (G) gelatin (H) HPMC (I) glutaraldehyde, QTP-F released of Gel/HPMC with increasing concentration Of (J) gelatin (K) HPMC (L) glutaraldehyde.

Figure 2. (A) 94.38/5.61 of Gel/HPMC and 2% GA (B) 90.56/9.43 of Gel/HPMC and 2% GA (C) 92.90/7.09 of Gel/HPMC and 1.5% GA showing porosity (D) 94.38/5.61 of Gel/HPMC and 2% GA (E) 90.56/9.43 of Gel/HPMC and 2% GA (F) 92.90/7.09 of Gel/HPMC and 1.5% GA showing 3-D structures dynamic swelling at pH 1.2 (G) 94.38/5.61 of Gel/HPMC and 2% GA (H) 90.56/9.43 of Gel/HPMC and 2% GA (I) 92.90/7.09 of Gel/HPMC and 1.5% GA showing 3-D structures dynamic swelling at pH 6.8.

Figure 3. Legend surface morphology of Gel/HPMC hydrogel formulations (A) S₃ (B) S₆ (C) S₇.

Figure 4. Cumulative % release of QTF-F from Gel/HPMC hydrogels (A) (90.75/9.24) using 2% of GA (B) (92.9/7.09) using 2% of GA (C) (94.38/5.61) using 2% of GA (D) (94.73/5.26) using 2% of GA (E) (93.38/6.61) using 2% of GA (F) (90.56/9.43) using 2% of GA (G) (90.56/9.43) using 1.5% of GA (H) (90.56/9.43) using 3.5% of GA (I) (90.56/9.43) using 4.6% of GA, after 12 hours at pH 1.2 (•), pH 6.8 (▪) and pH 7.4 (▲).

Figure 5. (AA) Synthesis of Gel/HPMC hydrogel (BB) FTIR of (A) Gelatin (B) QTP-F (C) HPMC (D) Unloaded hydrogel (E) Loaded hydrogel (CC) DSC of FTIR of (A) Gelatin (B) QTP-F (C) HPMC (D) Unloaded hydrogel (E) Loaded hydrogel.

Figure 6. Sample HPLC chromatogram of QTP-F test hydrogel in plasma (A), Plasma drug concentration (µg/ml) profile of QTP-F test hydrogel in-vivo (B), Sample HPLC chromatogram of QTP-F reference tablet (Qusel^®, Hilton Pharma, Karachi, Pakistan) in plasma (C), Plasma drug concentration (µg/ml) profile of QTP-F reference tablet (Qusel^®, Hilton Pharma, Karachi, Pakistan).