Figures & data
Figure 2. Cumulative CEQ release from CEQ -PLA-microspheres in PBS (pH 7.4). In vitro release kinetics were obtained at 37 ± 1 °C by dialysis. CEQ release from the drug stock solution was used as control. CEQ loading was 18.7 ± 1.2%. Data are presented as mean ± SD, n = 3.
![Figure 2. Cumulative CEQ release from CEQ -PLA-microspheres in PBS (pH 7.4). In vitro release kinetics were obtained at 37 ± 1 °C by dialysis. CEQ release from the drug stock solution was used as control. CEQ loading was 18.7 ± 1.2%. Data are presented as mean ± SD, n = 3.](/cms/asset/835573a5-5255-4ed7-9b66-7898c234ef2d/idrd_a_1461958_f0002_b.jpg)
Figure 3. The absorbance at a wavelength of 550 nm represented phagocytosis by macrophages. Data are means ± SD, n = 6. a–dMeans at that time period for phagocytosis were statistically different (p < .05).
![Figure 3. The absorbance at a wavelength of 550 nm represented phagocytosis by macrophages. Data are means ± SD, n = 6. a–dMeans at that time period for phagocytosis were statistically different (p < .05).](/cms/asset/3f1884c5-1be4-4bc1-8573-3ca3686abd4c/idrd_a_1461958_f0003_b.jpg)
Figure 4. Klebsiella pneumonia bacterial counts in lung following i.v. administration of a single 12.5 mg/kg dose of CEQ-loaded microspheres or CEQ injection. Each point represents the mean ± SD, n = 6. *p < .05 compared with KPD model group. #p < .05 compared with CEQ injection group.
![Figure 4. Klebsiella pneumonia bacterial counts in lung following i.v. administration of a single 12.5 mg/kg dose of CEQ-loaded microspheres or CEQ injection. Each point represents the mean ± SD, n = 6. *p < .05 compared with KPD model group. #p < .05 compared with CEQ injection group.](/cms/asset/ebbf3ef1-f766-4501-92e6-c524a2fa0cd8/idrd_a_1461958_f0004_c.jpg)
Figure 5. Cytokines in bronchoalveolar lavage fluid. The columns represent the levels of TNF-α (A), IL-1β (B), IL-8 (C), IL-4 (D), IL-10 (E) and IL-13 (F) in four groups of rats: control (no infection or drug), KPD model (infected, no drug), KPD with CEQ injection and KPD with CEQ-loaded PLA-microspheres. Results are given as mean ± SD, n = 6. *p < .05, KPD with injection versus KPD model. #p < .05, KPD with CEQ-PLA-Ms versus KPD with injection.
![Figure 5. Cytokines in bronchoalveolar lavage fluid. The columns represent the levels of TNF-α (A), IL-1β (B), IL-8 (C), IL-4 (D), IL-10 (E) and IL-13 (F) in four groups of rats: control (no infection or drug), KPD model (infected, no drug), KPD with CEQ injection and KPD with CEQ-loaded PLA-microspheres. Results are given as mean ± SD, n = 6. *p < .05, KPD with injection versus KPD model. #p < .05, KPD with CEQ-PLA-Ms versus KPD with injection.](/cms/asset/6b161bf7-322f-4f03-b0c1-3379457081b5/idrd_a_1461958_f0005_b.jpg)