http://orcid.org/0000-0002-4003-0381
Figures & data
Figure 1. Proposed DDS for dual drug release.
Figure 2. Preparation of the DDS.
Figure 3. (a) DOX and (b) CPT release profile of CPT@MSN-hyd-PEG-hyd-DOX at different pH values under stirring at 100 rpm and at t = 37 °C.
Figure 4. CLSM images of the uptake of CPT@MSN-hyd-PEG-hyd-DOX scale bar 20 µm. (a) corresponds to fluorescein diacetate (FDA) fluorescence, (b) CPT fluorescence, (c) DOX fluorescence and (d) DOX and CPT merged images.
Figure 5. (a) Transmission electron microscopy (TEM) images of HeLa cells incubated for 4 h with 50 µg mL−1 of CPT@MSN-hyd-PEG-hyd-DOX (b) a cluster of nanoparticles that have escaped from the endosome (c) internalization of the nanoparticles.
Figure 6. Cell viability of (a) HeLa cells and (b) U-87 MG cells incubated with MSN-(NH2), MSN-(NH2)i(CHO)o, MSN-hyd-PEG-hyd-DOX, CPT@MSN-hyd-PEG-hyd and CPT@MSN-hyd-PEG-hyd-DOX. Data represented as mean ± SD, *p < .05 and **p < .01. The concentration of free DOX is the released drug at pH = 5.5.
