Advances in polymeric nano-delivery systems targeting hair follicles for the treatment of acne

Figures & data

Figure 1. Three strategies for targeting hair follicles with polymer nano drug carrier (By figdraw).

Table 1. Reletive information of some PNPs targeting hair follicle for acne treatment.

Drugs	Carrier composition	Size(nm)	Zate(mV)	Target site	Stimuli	References
Tretinoin	Eudragit RS100	116.3	30			(Ebrahimi et al. 2021)
Clindamycin	Chitosan	362 ± 19	+27.7 ± 0.9	sebaceous glandunits		(Takeuchi, Suzuki, et al. 2017)
	Yaluronic acid	417 ± 9	−30.2 ± 2.7
Azelaic acid	PLGA	252.23 ± 23.1	11.3 ± 1.4	follicularunit		(Reis et al. 2014)
Dexamethasone	Eudragit^®L100	303.1 ± 5.5		HFs orinner root sheath	pH-sensitive	(Dong et al. 2019)
Tretinoin	Poly-ɛ-caprolactone	CCM:228 ± 0.8 SFO:222 ± 0.8	CCM:-7.27 ± 0.66 SFO:-5.72 ± 1.36			(Ourique et al. 2008)
Tretinoin	Polyolprepolymer-2			follicularopening and top of the PSU		(Skov, Quigley, and Bucks 1997)
Adapalene	ABA triblock copolymer PEG5K-b-oligo			HFs and upper epidermis		(Ramezanli, Zhang, and Michniak-Kohn 2017)
Benzoyl peroxide	Chitosan	approximately 50		P.acnes		(Friedman et al. 2013)
Clindamycin HCl	Carboxymethyl chitosan	318.40 ± 7.56			Ultrasound-assisted	(Chaiwarit et al. 2022)
Spironolactone	Poly-ε-caprolactone	180.0 ± 1.6/126.8 ± 1.0	−15.3 ± 1.3/ −12.1 ± 2.4	HFs		(Ferreira-Nunes et al. 2021)
	EL100	102.7 ± 7.1	−19.0 ± 1.2
Adapalene	Eudragit^®EPO	125.8 ± 3.5	18.4 ± 2.9		Acid-Responsive	(Folle et al. 2021)
Thymol	PLGA	below 200	around − 28	HFs and P.acnes		(Guo et al. 2014)

Table 2. Reletive information of some PMs targeting hair follicle for acne treatment.

Drugs	Solubility	Carrier composition	Size(nm)	Target site	References
Adapalene	Almost insoluble in water	CMC-Na	Below 20	HFs	(Kandekar et al. 2018)
Benzoyl peroxide	Low water solubility	Pluronic^® F127	25.3 ± 0.3	HFs	(Kahraman et al. 2016)
Retinoic acid	Insoluble in water	mPEG-dihexPLA	71.7 ∼ 105.7	PSU	(Lapteva et al. 2015)
Lauric acid	Insoluble in water	PCL-PEG-PCL	Below 100	P. acnes	(Tran et al. 2016)
Isotretinoin and Clindamycin phosphate	Insoluble in water and highly water soluble	Phosphatidylcholine	19.3 ± 1.03	P. acnes	(Sharma et al. 2021)
Spironolactone	Low water solubility	mPEG-dihexPLA	20	PSU	(Dahmana et al. 2021)

Table 3. Reletive information of some NGs targeting hair follicle for acne treatment.

Type of NGs	Drugs	Carrier composition	Size(nm)	Target site	Stimuli	References
Dendronized polymer	dexamethasone and betamethasone	poly(N-isopropylacrylamide)	95 ± 1.9	SC	Temperature	(Giulbudagian et al. 2016)
Transfersome	Adapalene	Carbopol 934	354.22	SC	pH	(Vasanth et al. 2020)
Ethosomal	Retinyl Palmitate	Chitosan	195.8 ± 5.45	SC		(Salem et al. 2021)
Nanocrystal	Tanshinone	carboxymethyl chitosan and oxidized hyaluronic acid	223.67 ± 4.03		pH	(Tang et al. 2022)
Niosomes	Rosemarinic acid	Carbopol 940	814.2			(Budhiraja and Dhingra 2015)
Ethosomes	Cryptotanshinone	Carbopol 974 and PEG-400	69.1 ± 1.9			(Yu et al. 2016)
Nanospheres	Adapalene	poly-ε-caprolactone/ HPMC/HA	107.5 ± 8.19	Epidermal layer and HFs		(Sallam and Marín Boscá 2017)
Nanocrystal	Curcumin	CMC-Na	267	the lower part of the infundibulum of a HFs		(Pelikh et al. 2021)
Nanocrystal	Azelaic acid	Pluronic^® F127	269.9 ± 14.8	SC		(Tomić et al. 2021)
Niosomes	Cryptotanshinone	Polyacrylate 700	less than 150	epidermis		(Wang et al. 2020)

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Data availability statement

Data sharing is not applicable to this article as no new data were created or analyzed in this study.