Influence of the Hemoglobin Solution HBOC-201 on Tissue Oxygenation in the Rat R1H-Tumor

Figures & data

Table 1. Mean arterial blood pressure (MAP) and oxygenation parameters of animals treated with 0.3 g/kg HBOC-201, carbogen alone, and a combination of HBOC-201 and carbogen

	HBOC-201				Carbogen				HBOC-201 + Carbogen
min	MAP (mmHg)	paO2 (mmHg)	paCO2 (mmHg)	pHb (g/dl)	MAP (mmHg)	paO2 (mmHg)	paCO2 (mmHg)	pHb (g/dl)	MAP (mmHg)	paO2 (mmHg)	paCO2 (mmHg)	pHb (g/dl)
0	87 ± 9	98 ± 28	31 ± 8	0 ± 0	86 ± 22	89 ± 28	30 ± 4	0 ± 0	92 ± 8	91 ± 21	33 ± 7	0 ± 0
15	132 ± 38^#	98 ± 24	31 ± 7	1 ± 0.08^#	82 ± 9^†	416 ± 130^#	52 ± 4^#	0 ± 0^†	136 ± 24^#	437 ± 106^#	55 ± 8^#	1 ± 0.1^#
60	104 ± 32^#	92 ± 16	32 ± 7	0.9 ± 0.06^#	81 ± 15^†	417 ± 136^#	51 ± 5^#	0 ± 0	113 ± 24^#	461 ± 98^#	54 ± 5^#	0.8 ± 0.08^#

MAP = mean arterial pressure, paO₂ = arterial oxygen partial pressure, paCO₂ = arterial carbon dioxid partial pressure, pHb = plasmatic concentration of HBOC-201.*p < 0.05 versus HBOC-201, ^#p < 0.05 versus 0 min, ^†p < 0.05 versus HBOC-201 and carbogen

Figure 1 Mean tpO₂ within the R1H tumor 0, 15 and 60 minutes after administration of 0.3 g/kg HBOC-201, carbogen alone, or a combination of HBOC-201 and carbogen (^#p < 0.05 vs. 0 min). Data are presented as mean ± SD.

Figure 2 Mean tpO₂ of opposite skeletal muscle 0, 15 and 60 minutes after administration of 0.3 g/kg HBOC-201, carbogen alone, or a combination of HBOC-201 and carbogen (*p < 0.05 vs. HBOC-201 alone, ^#p < 0.05 vs. 0 min). Data are presented as mean ± SD.