Immune Effects of Decreasing Low-Molecular Weight Hemoglobin Components of Hemoglobin-Based Oxygen Carriers (HBOC) in a Swine Model of Severe Controlled Hemorrhagic Shock

C. VanderMolen Naval Medical Research Center, Combat Casualty Department, Silver Spring, MD, USA

N. Malkevich Naval Medical Research Center, Combat Casualty Department, Silver Spring, MD, USACorrespondence[email protected]

N. Philbin Naval Medical Research Center, Combat Casualty Department, Silver Spring, MD, USA

J. Rice Naval Medical Research Center, Combat Casualty Department, Silver Spring, MD, USA

S. Collier Naval Medical Research Center, Combat Casualty Department, Silver Spring, MD, USA

C. Hall Naval Medical Research Center, Combat Casualty Department, Silver Spring, MD, USA

S. Ahlers Naval Medical Research Center, Combat Casualty Department, Silver Spring, MD, USA

R. McCarron Naval Medical Research Center, Combat Casualty Department, Silver Spring, MD, USA

D. Freilich Naval Medical Research Center, Combat Casualty Department, Silver Spring, MD, USA

G. McGwin Department of Epidemiology, Birmingham, AL, USA; Section of Trauma, Burns, and Surgical Critical Care, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA

L. Bruce Pearce Biopure Corporation, Cambridge, MA, USA

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Figures & data

Figure 1 Apoptosis in total leukocytes and lymphocytes before and after HS and resuscitation. 1A. Apoptosis in total leukocyte population. Apoptosis data is presented as mean percentages of Annexin + /PI − cells±SEM within “total cells” gate. Neutrophils, monocytes and lymphocytes were included in the flow cytometry analysis. All groups exhibited an overtime increase of apoptosis, however, no group differences were observed. 1B. Apoptosis in lymphocyte population. Apoptosis data is presented as mean percentages of Annexin + /PI − cells±SEM within “lymphocytic cells” gate. All groups exhibited an overtime increase of apoptosis, however, no group differences were observed. Black bar − 31TD; grey bar − 2TD; open bar − 0.4 TD.

Table 1. Immune responses of 31 TD, 2 TD and 0.4 TD treatment groups before and after HS and resuscitation

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Immune Effects of Decreasing Low-Molecular Weight Hemoglobin Components of Hemoglobin-Based Oxygen Carriers (HBOC) in a Swine Model of Severe Controlled Hemorrhagic Shock

Table 1. Immune responses of 31 TD, 2 TD and 0.4 TD treatment groups before and after HS and resuscitation

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Immune Effects of Decreasing Low-Molecular Weight Hemoglobin Components of Hemoglobin-Based Oxygen Carriers (HBOC) in a Swine Model of Severe Controlled Hemorrhagic Shock

Figures & data

Table 1. Immune responses of 31 TD, 2 TD and 0.4 TD treatment groups before and after HS and resuscitation

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