Figures & data
Figure 1. Systemic levels of urea in rats infused with 33% volume of NanoRBC, LactRing, SFHb, PolyHb or autologous RBC (Mean±S.E.).
Figure 2. Systemic levels of creatinine in rats infused with 33% volume of NanoRBC, LactRing, SFHb, PolyHb or autologous RBC (Mean±S.E.).
Figure 3. Systemic levels of uric acid in rats infused with 33% volume of NanoHb, LactRing, SFHb, PolyHb or autologous RBC (Mean±S.E.).
Figure 4. Systemic levels of calcium (a), phosphorus (b) in rats infused with 33% volume of NanoRBC, LactRing, SFHb, PolyHb or RBC (Mean±S.E.).
Figure 5. Systemic levels of calcium sodium (a) and chloride (b) in rats infused with 33% volume of NanoHb, LactRing, SFHb, PolyHb or RBC (Mean±S.E.).
Figure 6. Histology of renal glomeruli in rats toploading with NanoRBC (a), LactRing (b), SFHb (c), PolyHb (d) or RBC (e). Under light microscope, the renal glomeruli in rats of all groups did not show abnormality with normal number of renal glomeruli, no glomerular necrosis, distention or degeneration. H&E staining, ×400.
Figure 7. Histology of renal tubular system in rats toploading with NanoHb (a), LactRing (b), SFHb (c), PolyHb (d) or RBC (e). Under light microscope, in the groups a, b, d and e, the tubular system showed normal, no protein or other sediments within the tubular lumens. However, in the rats infused with SFHb (d), the proximal tubular necrosis was observed (arrows), and necrotic cell debris presented in the lumens of proximal tubules (arrow head), showing the ongoing necrosis in the kidney, although 3 weeks after SFHB injection. H&E staining, ×400.
