Effect of Artificial Oxygen Carrier with Chemotherapy on Tumor Hypoxia and Neovascularization

Figures & data

Figure 1.  volume was decreased sharply in G2,G3 and G4 after chemotherapy alone or/and combined with artificial oxygen carrier. *p < 0.01 vs.saline.

Figure 2.  tortuosity in peritumoral areas on day0,day3,day5 and day7 after innoculation. in (# p < 0.05 vs. cisplatin alone. * p < 0.05 vs.saline).

Figure 3.  area capillary density in peritumoral areas on day0,day3,day5 and day7 after respective treatment. (# p < 0.05 vs. cisplatin alone. * p < 0.05 vs.saline).

Table 1. Pimonidazole and HIF-1α expression in neoplasma (mean±S.E.M.)

Group	Number	Pimonidazole%	HIF-1α%
group 1	10	27.6±4.7	29.2±5.5
group 2	10	22.5±3.8	24.1±6.4
group 3	10	20.5±4.1*	22.5±4.7*
group 4	10	14.8±3.2* #	17.8±5.3* #

% percentage of tumor area staining positive for HIF-1aimmunoreactivity or pimonidazole binding. * p < 0.05 vs.saline # p < 0.05 vs. cisplatin alone. group 1 saline; group 2 cisplatin alone; group 3 cisplatin with PEG-Hb (0.3g/kg); group4 cisplatin with PEG-Hb(0.6/kg).