Evaluation of Bone Growth Using Artificial Bone Substitute (Osteoset®) and Platelet Gel Mixtures: A Preliminarily Study in Dogs

Figures & data

Figure 1.  Picture of the HTPG/Osteoset® material used in the study (experimental Group A).

Figure 2.  X-ray radiographic observations at (a) 2 weeks, (b) 4 weeks, (c) 8 weeks, and (d) 12 weeks. Group A: HTPG/Osteoset® material. Group B: Osteoset® material alone.

Table 1. The semi-quantitative evaluation of new bone formation

Implantation time	Group A	Group B
2 weeks	–	–
4 weeks	20–40%	5∼10%
8 weeks	40–60%	15–25%
12 weeks	80–90%	30–40%

Figure 3.  Histological observations of new bone structures at 12 weeks implanted with HTPG/Osteoset material or Osteoset® alone. New bone structures (black arrow) and blood vessels (white arrow) could be observed for cases in combination of HTPG and Osteoset®. (a) implanted with HTPG/Osteoset® material (Group A)×40; (b) implanted with HTPG/Osteoset® material (Group A)×100; (c) implanted with Osteoset® material only (Group B)×40; and (d) implanted with Osteoset® material only (Group B)×100. Hematoxylin and eosin stain.