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Original

Non-toxicity of IV Injected Perfluorocarbon Oxygen Carrier in an Animal Model of Liver Regeneration Following Surgical Injury

, , , , &
Pages 117-124 | Published online: 13 Aug 2009

Figures & data

Table 1. The experimental sub-groups

Table 2. Measured variables and units

Table 3. Weight changes, biochechemistry and hematology

Figure 1.  Liver regeneration projections, assuming linear re-growth. The rate of regeneration after liver injury and IV dosing of PFC or saline is not significantly different. The y-intercept indicates the amount of liver initially resected. A liver/BW value of 1.5 equates to approximately a 60% liver weight resection. The projected time to complete liver weight regeneration, i.e. to a liver/BW ratio of 3.5, is 7-8 days. This duration is in agreement with prior experience with this surgical model Citation18–23.

Figure 1.  Liver regeneration projections, assuming linear re-growth. The rate of regeneration after liver injury and IV dosing of PFC or saline is not significantly different. The y-intercept indicates the amount of liver initially resected. A liver/BW value of 1.5 equates to approximately a 60% liver weight resection. The projected time to complete liver weight regeneration, i.e. to a liver/BW ratio of 3.5, is 7-8 days. This duration is in agreement with prior experience with this surgical model Citation18–23.

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