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Journal of Liquid Chromatography & Related Technologies Volume 29, 2006 - Issue 13
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Modification of a Conventional High Performance Liquid Chromatograph for Use in High Speed Liquid Chromatography

Domingo Blanco Gomis Department of Physical and Analytical Chemistry, University of Oviedo, Oviedo, SpainCorrespondence[email protected]
,
Noé Sánchez Núñez Department of Physical and Analytical Chemistry, University of Oviedo, Oviedo, Spain
,
Elena Andrés García Department of Physical and Analytical Chemistry, University of Oviedo, Oviedo, Spain
,
Pilar Arias Abrodo Department of Physical and Analytical Chemistry, University of Oviedo, Oviedo, Spain
&
Dolores Gutiérrez Álvarez Department of Physical and Analytical Chemistry, University of Oviedo, Oviedo, Spain
Pages 1861-1875 | Received 30 Dec 2005, Accepted 29 Jan 2005, Published online: 10 Nov 2011
 
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Abstract

A practical procedure is described for the modification of a conventional HPLC system to a set‐up compatible with high speed HPLC requirements. A number of experimental parameters, such as extra‐column volume, extra‐column band broadening, effectiveness, and dwell volume, were examined to characterize and demonstrate the suitability of the modified system for use in high speed HPLC applications. In addition, an injector bypass is presented as an alternative to reduce the pressure damage suffered by short columns packed with microparticles.

Acknowledgment

The authors wish to acknowledge the financial support of the Spanish Ministry of Science and Technology, Project CTQ2004‐03271.

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