Abstract
The lipophilicity parameters R Mw of twenty-one uridine derivatives were determined by reverse phase thin layer chromatography (RP-TLC). Experiments were performed on RP-18 F254 plates with mixtures of methanol/water as the mobile phases. Amounts of methanol as an organic modifier were in the range 60–85% (v/v) in 5% increments. For nine compounds, logPexp values were determined by shake-flask method. A good correlation was found between logPexp and R Mw (r 0.96). Theoretical logP values for the studied compounds were calculated using nine different algorithms. A correlation matrix was formed to compare the experimental lipophilicity parameters: R Mw , logPexp and theoretical logP values. A good agreement between two experimental methods and theoretical logP values was achieved. The best agreement was obtained between AC/logP vs. logPexp, and R Mw (r 0.98 and 0.96, respectively).
ACKNOWLEDGMENT
Publication partly financed by the European Union within the European Regional Development Fund (POIG. 01.01.02-14-102/09).