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Journal of Liquid Chromatography & Related Technologies Volume 37, 2014 - Issue 3
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Original Articles

PREPARATIVE ISOLATION OF TETRANDRINE AND FANGCHINOLINE FROM RADIX STEPHANIA TETRANDRA USING REVERSED-PHASE FLASH CHROMATOGRAPHY

Zhisheng Xie School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, P.R. China; Guangdong Technology Research Center for Advanced Chinese Medicine, Guangzhou, P.R. China
,
Xinjun Xu School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, P.R. China; Guangdong Technology Research Center for Advanced Chinese Medicine, Guangzhou, P.R. ChinaCorrespondence[email protected]
,
Chunyan Xie School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, P.R. China; Guangdong Technology Research Center for Advanced Chinese Medicine, Guangzhou, P.R. China
,
Zhikun Liang School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, P.R. China; Guangdong Technology Research Center for Advanced Chinese Medicine, Guangzhou, P.R. China
,
Mei Yang School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, P.R. China; Guangdong Technology Research Center for Advanced Chinese Medicine, Guangzhou, P.R. China
,
Jieyun Huang School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, P.R. China; Guangdong Technology Research Center for Advanced Chinese Medicine, Guangzhou, P.R. China
&
Depo Yang School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, P.R. China; Guangdong Technology Research Center for Advanced Chinese Medicine, Guangzhou, P.R. China
 show all
Pages 343-352 | Published online: 13 Nov 2013
 
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Abstract

Tetrandrine and fangchinoline were successfully separated by reversed-phase flash chromatography on a manually-packed C18 column from Radix Stephania tetrandra. After recrystallization by acetone, 13 mg of fangchinoline and 21 mg of tetrandrine were obtained from 100 mg Stephania tetrandra extract, with their relative content 98.78% and 98.19%, respectively. Their structures were characterized by UV, IR, MS, and NMR. The established method was simple, fast, and reproducible, which can be applied to the preparation of reference substances of tetrandrine and fangchinoline.

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