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Research Article

On the plasticizing properties of divalproex sodium: physicochemical and spectroscopic characterization studies

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Pages 455-464 | Received 19 Nov 2017, Accepted 16 Aug 2018, Published online: 06 Nov 2018

Figures & data

Table 1. %DVS content of films.

Figure 1. Peak load for films containing different concentration of divalproex sodium in ethylcellulose (data represents mean ± SD, n = 3).

Figure 1. Peak load for films containing different concentration of divalproex sodium in ethylcellulose (data represents mean ± SD, n = 3).

Figure 2. Elongation of films containing different concentration of divalproex sodium in ethylcellulose (data represents mean ± SD, n = 3).

Figure 2. Elongation of films containing different concentration of divalproex sodium in ethylcellulose (data represents mean ± SD, n = 3).

Figure 3. Melt viscosity of ethylcellulose and films containing different concentration divalproex sodium as a function of temperature.

Figure 3. Melt viscosity of ethylcellulose and films containing different concentration divalproex sodium as a function of temperature.

Figure 4. DSC thermogram of divalproex sodium (DVS) in ethylcellulase (ES), ethylcellulose, and DVS films containing different concentration divalproex sodium.

Figure 4. DSC thermogram of divalproex sodium (DVS) in ethylcellulase (ES), ethylcellulose, and DVS films containing different concentration divalproex sodium.

Figure 5. X-ray diffractograms of divalproex sodium, ethylcellulose, and ethylcellulose films containing different concentration of divalproex sodium.

Figure 5. X-ray diffractograms of divalproex sodium, ethylcellulose, and ethylcellulose films containing different concentration of divalproex sodium.

Figure 6. Thermogravimetric profile of divalproex sodium, ethylcellulose, and 50% ethylcellulose (by dry polymer weight) in EC.

Figure 6. Thermogravimetric profile of divalproex sodium, ethylcellulose, and 50% ethylcellulose (by dry polymer weight) in EC.

Figure 7. Polarized microscopic image(40×) of ethylcellulose film containing (A) 10% divalproex sodium of ethylcellulose by weight, (B) 20% divalproex sodium of ethylcellulose by weight, (C) 30% divalproex sodium of ethylcellulose by weight, (D) 40% divalproex sodium of ethylcellulose by weight, (E) 50% divalproex sodium of ethylcellulose by weight.

Figure 7. Polarized microscopic image(40×) of ethylcellulose film containing (A) 10% divalproex sodium of ethylcellulose by weight, (B) 20% divalproex sodium of ethylcellulose by weight, (C) 30% divalproex sodium of ethylcellulose by weight, (D) 40% divalproex sodium of ethylcellulose by weight, (E) 50% divalproex sodium of ethylcellulose by weight.

Figure 8. FTIR spectra of divalproex sodium, ethylcellulose and film with 50% divalproex sodium (by dry weight of polymer) in ethylcellulose.

Figure 8. FTIR spectra of divalproex sodium, ethylcellulose and film with 50% divalproex sodium (by dry weight of polymer) in ethylcellulose.

Figure 9. Raman spectra of divalproex sodium, ethylcellulose and film containing 50% divalproex sodium(by polymer dry weight) in ethylcellulose.

Figure 9. Raman spectra of divalproex sodium, ethylcellulose and film containing 50% divalproex sodium(by polymer dry weight) in ethylcellulose.

Figure 10. X-ray diffractograms of divalproex sodium, ethylcellulose and ethylcellulose films containing different concentration of divalproex sodium (2 weeks, 45 °C/75% RH, open),.

Figure 10. X-ray diffractograms of divalproex sodium, ethylcellulose and ethylcellulose films containing different concentration of divalproex sodium (2 weeks, 45 °C/75% RH, open),.

Figure 11. DSC thermogram of divalproex sodium, ethylcellulose, and ethylcellulose films containing different concentration of divalproex sodium (2 weeks, 45 °C/75% RH, open).

Figure 11. DSC thermogram of divalproex sodium, ethylcellulose, and ethylcellulose films containing different concentration of divalproex sodium (2 weeks, 45 °C/75% RH, open).