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Pharmaceutical Development and Technology Volume 12, 2007 - Issue 2
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Research Article

Novel Potential Drug Against T. cruzi and Its Interaction with Surfactant Micelles

Carlota O. Rangel-Yagui Department of Biochemical and Pharmaceutical Technology, Faculty of Pharmacy, University of São Paulo, São Paulo, Brazil; Department of Pharmacy, Faculty of Pharmacy, University of São Paulo, São Paulo, Brazil
,
Helen W.L. Hsu Department of Biochemical and Pharmaceutical Technology, Faculty of Pharmacy, University of São Paulo, São Paulo, Brazil
,
Leandro R.S. Barbosa Institute of Physics, University of São Paulo, São Paulo, Brazil
,
Wilker Caetano Institute of Physics, University of São Paulo, São Paulo, Brazil
,
Adalberto Pessoa Jr Department of Biochemical and Pharmaceutical Technology, Faculty of Pharmacy, University of São Paulo, São Paulo, Brazil
,
Leoberto C. Tavares Department of Biochemical and Pharmaceutical Technology, Faculty of Pharmacy, University of São Paulo, São Paulo, Brazil
&
Rosangela Itri Institute of Physics, University of São Paulo, São Paulo, Brazil
 show all
Pages 183-192 | Received 01 Jun 2006, Accepted 25 Oct 2006, Published online: 07 Oct 2008
 
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Abstract

The interaction of 5-nitro-2-furfurilylidene benzhydrazide (5NFB), potential anti-trypanosomal compound, with micellar solutions was studied. The results indicated that 50 μg of 5NFB completely kills 20 million T. cruzi epimastigote cells within 3 days, whereas the same amount of benznidazole kills 30% of the cells after 4 days. 5NFB solubility in surfactants solutions (SDS, DTAB, C12EO8) increased linearly with surfactant concentration. According to small angle X-ray scattering (SAXS), 5NFB does not affect micellar structural features. A comparison between C12EO8 effects on T. cruzi epimastigote cells and on erythrocytes showed that surfactant lytic effect is stronger in parasite cells, enlightening the potential of 5NFB micellar formulations.

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